Pregled bibliografske jedinice broj: 679128
Myeloma cell morphology and morphometry in correlation with clinical stages and survival
Myeloma cell morphology and morphometry in correlation with clinical stages and survival // Diagnostic cytopathology, 41 (2013), 11; 947-954 doi:10.1002/dc.22986 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 679128 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Myeloma cell morphology and morphometry in correlation with clinical stages and survival
Autori
Seili-Bekafigo, Irena ; Valković, Toni ; Babarović, Emina ; Duletić-Načinović, Antica ; Jonjić, Nives
Izvornik
Diagnostic cytopathology (8755-1039) 41
(2013), 11;
947-954
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
multiple myeloma; plasma cell morphology; morphometry; clinical stages; survival
Sažetak
Multiple myeloma (MM) shows great variability in clinical course of the disease, and survival varies between a few months and more than 10 years. Myeloma plasma cells (PCs) can appear completely “normal” in morphology, but can also be overtly atypical, polymorphic, immature, as well as in all transitional forms. The aim of this investigation was to analyze the relationship between various morphological and morphometric parameters of myeloma cells, common staging/prognostic systems and survival in patients with MM. Sixty newly diagnosed MM patients were included in the study. Morphologic as well as basic morphometric features of myeloma PCs were analyzed in bone marrow (BM) aspirates, and compared with patient's clinical stage determined by Durie–Salmon and International Staging System, and with survival. We conclude that myeloma cell morphology has a prognostic potential. The most significant morphologic characteristics indicating shorter survival are: finding of >15% atypical PCs in BM aspirate, largest nuclear diameter/largest cytoplasmatic diameter of PCs ratio (maxND/maxCD)≥0.65, and anisocytosis expressed as standard deviation of maxCD ≥4.2 µm. Furthermore, PCs with irregular nuclei and absence of paranuclear clearing of the cytoplasm indicate more advanced stage of disease and worse prognosis. This preliminary results obtained on myeloma cells morphology and morphometry should be confirmed in the larger study which will include cytogenetic data as well as a therapeutic protocols applied.
Izvorni jezik
Engleski
POVEZANOST RADA
Projekti:
062-0620095-0078 - Uloga osteopontina u progresiji tumora (Lučin, Ksenija, MZOS ) ( CroRIS)
062-0620095-0082 - REGULACIJSKI ČIMBENICI ANGIOGENEZE U PROGNOZI TUMORA (Jonjić, Nives, MZOS ) ( CroRIS)
Ustanove:
Medicinski fakultet, Rijeka,
Klinički bolnički centar Rijeka
Profili:
Antica Duletić-Načinović
(autor)
Emina Babarović
(autor)
Toni Valković
(autor)
Irena Seili-Bekafigo
(autor)
Nives Jonjić
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE