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Pregled bibliografske jedinice broj: 679128

Myeloma cell morphology and morphometry in correlation with clinical stages and survival


Seili-Bekafigo, Irena; Valković, Toni; Babarović, Emina; Duletić-Načinović, Antica; Jonjić, Nives
Myeloma cell morphology and morphometry in correlation with clinical stages and survival // Diagnostic cytopathology, 41 (2013), 11; 947-954 doi:10.1002/dc.22986 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 679128 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Myeloma cell morphology and morphometry in correlation with clinical stages and survival

Autori
Seili-Bekafigo, Irena ; Valković, Toni ; Babarović, Emina ; Duletić-Načinović, Antica ; Jonjić, Nives

Izvornik
Diagnostic cytopathology (8755-1039) 41 (2013), 11; 947-954

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
multiple myeloma; plasma cell morphology; morphometry; clinical stages; survival

Sažetak
Multiple myeloma (MM) shows great variability in clinical course of the disease, and survival varies between a few months and more than 10 years. Myeloma plasma cells (PCs) can appear completely “normal” in morphology, but can also be overtly atypical, polymorphic, immature, as well as in all transitional forms. The aim of this investigation was to analyze the relationship between various morphological and morphometric parameters of myeloma cells, common staging/prognostic systems and survival in patients with MM. Sixty newly diagnosed MM patients were included in the study. Morphologic as well as basic morphometric features of myeloma PCs were analyzed in bone marrow (BM) aspirates, and compared with patient's clinical stage determined by Durie–Salmon and International Staging System, and with survival. We conclude that myeloma cell morphology has a prognostic potential. The most significant morphologic characteristics indicating shorter survival are: finding of >15% atypical PCs in BM aspirate, largest nuclear diameter/largest cytoplasmatic diameter of PCs ratio (maxND/maxCD)≥0.65, and anisocytosis expressed as standard deviation of maxCD ≥4.2 µm. Furthermore, PCs with irregular nuclei and absence of paranuclear clearing of the cytoplasm indicate more advanced stage of disease and worse prognosis. This preliminary results obtained on myeloma cells morphology and morphometry should be confirmed in the larger study which will include cytogenetic data as well as a therapeutic protocols applied.

Izvorni jezik
Engleski



POVEZANOST RADA


Projekti:
062-0620095-0078 - Uloga osteopontina u progresiji tumora (Lučin, Ksenija, MZOS ) ( CroRIS)
062-0620095-0082 - REGULACIJSKI ČIMBENICI ANGIOGENEZE U PROGNOZI TUMORA (Jonjić, Nives, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Rijeka,
Klinički bolnički centar Rijeka

Poveznice na cjeloviti tekst rada:

doi onlinelibrary.wiley.com

Citiraj ovu publikaciju:

Seili-Bekafigo, Irena; Valković, Toni; Babarović, Emina; Duletić-Načinović, Antica; Jonjić, Nives
Myeloma cell morphology and morphometry in correlation with clinical stages and survival // Diagnostic cytopathology, 41 (2013), 11; 947-954 doi:10.1002/dc.22986 (međunarodna recenzija, članak, znanstveni)
Seili-Bekafigo, I., Valković, T., Babarović, E., Duletić-Načinović, A. & Jonjić, N. (2013) Myeloma cell morphology and morphometry in correlation with clinical stages and survival. Diagnostic cytopathology, 41 (11), 947-954 doi:10.1002/dc.22986.
@article{article, author = {Seili-Bekafigo, Irena and Valkovi\'{c}, Toni and Babarovi\'{c}, Emina and Duleti\'{c}-Na\v{c}inovi\'{c}, Antica and Jonji\'{c}, Nives}, year = {2013}, pages = {947-954}, DOI = {10.1002/dc.22986}, keywords = {multiple myeloma, plasma cell morphology, morphometry, clinical stages, survival}, journal = {Diagnostic cytopathology}, doi = {10.1002/dc.22986}, volume = {41}, number = {11}, issn = {8755-1039}, title = {Myeloma cell morphology and morphometry in correlation with clinical stages and survival}, keyword = {multiple myeloma, plasma cell morphology, morphometry, clinical stages, survival} }
@article{article, author = {Seili-Bekafigo, Irena and Valkovi\'{c}, Toni and Babarovi\'{c}, Emina and Duleti\'{c}-Na\v{c}inovi\'{c}, Antica and Jonji\'{c}, Nives}, year = {2013}, pages = {947-954}, DOI = {10.1002/dc.22986}, keywords = {multiple myeloma, plasma cell morphology, morphometry, clinical stages, survival}, journal = {Diagnostic cytopathology}, doi = {10.1002/dc.22986}, volume = {41}, number = {11}, issn = {8755-1039}, title = {Myeloma cell morphology and morphometry in correlation with clinical stages and survival}, keyword = {multiple myeloma, plasma cell morphology, morphometry, clinical stages, survival} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati:





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