Pregled bibliografske jedinice broj: 678458
Modulating telomerase activity in tumor patients by targeting dyskerin binding site for hTR.
Modulating telomerase activity in tumor patients by targeting dyskerin binding site for hTR. // Medical hypotheses, 79 (2012), 3; 319-320 doi:10.1016/j.mehy.2012.05.021 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 678458 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Modulating telomerase activity in tumor patients by targeting dyskerin binding site for hTR.
Autori
Katunarić, Miljenko ; Zamolo, Gordana
Izvornik
Medical hypotheses (0306-9877) 79
(2012), 3;
319-320
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
Telomerase ; Dyskerin ; hTR
Sažetak
Telomeres shortening, which leads to apoptosis, is prevented by telomerase adding small repeated segments of DNA to the telomeres. The telomerase level has been correlated with progression of several cancer types, including acute leukemia, breast, prostate, lung cancer and melanoma. Suppression of telomerase activity was found to reduce metastatic potential but could have serious side effects in normal proliferative cells. One of the proteins stabilizing the telomerase complex called dyskerin reduces the maximum telomerase activity. We suggest a possible therapeutic agent which would disable the interaction of dyskerin and telomerase, but would not completely inhibit telomerase activity.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Projekti:
062-0000000-3545 - Telomerazna aktivnost i imunofenotipske karakteristike limfocita u melanomu kože (Zamolo, Gordana, MZOS ) ( CroRIS)
062-0620239-0197 - Imunološki mehanizmi u patogenezi psorijaze (Kaštelan, Marija, MZOS ) ( CroRIS)
Ustanove:
Medicinski fakultet, Rijeka
Poveznice na cjeloviti tekst rada:
Pristup cjelovitom tekstu rada doi dx.doi.org www.sciencedirect.comCitiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE