Naslov
EXPRESSION OF Ki-67 IN CANINE CIRCUMANAL GLAND TUMORS AND NORMAL CIRCUMANAL GLAND

Autori
Šoštarić-Zuckermann, Ivan-Conrado ; Gudan Kurilj, Andrea ; Severin, Krešimir ; Artuković Branka ; Beck, Ana ; Hohšteter, Marko ; Medven, Lidija ; Huber Doroteja ; Grabarević, Željko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Proceedings of the 31th meeteng of the European Society of Veterinary Pathology and the European College of Veterinary Pathologists 4th-7th September. / Smith, Ken - London : Delhi, 2013, 153-153

Skup
31th meeteng of the European Society of Veterinary Pathology and the European College of Veterinary Pathologists 4th-7th September.

Mjesto i datum
London, Ujedinjeno Kraljevstvo, 04.09.2013. - 07.09.2013

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
tumori cirkunamalne žlijezde; pas; Ki-67; imunohistokemija
(circumanal glands tumors; dog; Ki-67; immunohistochemistry)

Sažetak
Introduction: Circumanal gland (CG) tumours comprise a group of common canine skin tumours that arise from the modified sebaceous glands located in the dermis of cutaneous zone of anus. The aim of this study was to detect the proliferating capacity of these tumours using Ki-67 immunohistochemical (IHC) marker. Materials and Methods: A total of 64 samples (10 normal circumanal glands, 15 CG adenomas, 11 CG epitheliomas, 21 well differentiated CG carcinomas and 7 poorly differentiated carcinomas) were analysed using Ki-67 IHC marker (MIB-1, Dako). Results: Average values of Ki-67 expressions within cells were as follows: normal CG – 5.7% ; CG adenomas – 4.9% ; CG epitheliomas – 14.4% ; well differentiated CG carcinomas – 16.4% ; poorly differentiated CG carcinomas – 20.8%. Significant differences between these values were spotted between normal CG and either well differentiated or poorly differentiated carcinomas (p<0.01) ; between CG adenomas and CG epitheliomas (p<0.05) ; between CG adenomas and either well differentiated or poorly differentiated carcinomas (p<0.01). Conclusions: The results show overall quite low Ki-67 proliferation index (PI) of these tumours. The PI values of CG epitheliomas, well differentiated CG carcinomas and poorly differentiated CG carcinomas are comparable. However, there are significant differences between malignant variants of these tumours and normal CG or CG adenoma.

Izvorni jezik
Engleski

Znanstvena područja
Veterinarska medicina

POVEZANOST RADA