Naslov
Hedgehog signaling in cancer and therapeutic potential

Autori
Levanat, Sonja ; Car, Diana ; Sabol, Maja ; Musani, Vesna ; Ozretic, Petar, Gojevic, Ante ; Oreskovic, Slavko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Kancerološka sekcija SLD i sekcija sestara u onkologiji UMSTBS / Srpsko lekarsko društvo Kancerološka sekcija - Beograd : Kancerološka sekcija SLD, 2012, 25-25

ISBN
978-86-6061-049-4

Skup
Kancerološka nedelja

Mjesto i datum
Beograd, Srbija, 30.11.2012

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Hedgehog signaling; cancer; therapy

Sažetak
The Hedgehog-Gli (Hh-Gli) signaling pathway is a developmental pathway, which is often found aberrantly active in various tumors. The pathway is a highly coordinated and orchestrated network involving binding of the ligand Hedgehog (Hh) to its receptor, a twelve transmembrane protein, Patched (Ptch). This causes Ptch to release its repression over the coreceptor Smoothened (Smo), a seven transmembrane protein and triggers a cascade of events in the cytoplasm leading to activation of the transcription factor Gli and transcription of target genes. The Gli proteins are regulated by the Suppressor of Fused (SuFu), Protein Kinase A (PKA), Glycogen Synthase Kinase 3β (GSK3β) and Casein Kinase 1 (CK1). The involvement of the Hh-Gli signaling pathway in a variety of human cancers based on preclinical in vitro and in vivo data demonstrate a role of this pathway in cancer pathogenesis, self-renewal and chemotherapy resistance. Our recent results on colon cancer and ovarian carcinoma will be presented as examples of the involvment of the Hh-Gli signaling pathway in the pathogenesis of different tumors, and will show different levels of pathway alterations. To date several Smo inhibitors have been proposed as potential candidates for cancer therapy either as a single agent or in combination regimens with conventional chemotherapy. There is a need for better understanding of the modes of Hh-Gli pathway regulation in different tumors, its role in tumor response to traditional therapy, as well as the interactions of the Hh-Gli pathway with other signaling pathways in order to develop better therapies based on combinations with inhibitors of the Hh-Gli signaling pathway

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA