Pregled bibliografske jedinice broj: 673730
AICAR induces differentiation of acute myeloid leukemia cells
AICAR induces differentiation of acute myeloid leukemia cells // Leukemia & lymphoma, 55 (2014), 10; 2375-2383 doi:10.3109/10428194.2013.876633 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 673730 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
AICAR induces differentiation of acute myeloid leukemia cells
Autori
Lalić, Hrvoje ; Dembitz, Vilma ; Lukinović-Škudar, Vesna ; Banfić, Hrvoje ; Višnjić, Dora
Izvornik
Leukemia & lymphoma (1042-8194) 55
(2014), 10;
2375-2383
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
AICAR; differentiation markers; leukemia
Sažetak
AMP-activated kinase (AMPK) modulators have been shown to exert cytotoxic activity in hematological malignancies, but their role in differentiation of acute myeloid leukemia (AML) is less explored. In this study, the effects of AMPK agonists on all- trans retinoic acid (ATRA)-mediated differentiation of acute promyelocytic leukemia (APL) and non-APL AML cell lines were investigated. The results show that APMK agonists inhibit growth of myeloblastic HL-60, promyelocytic NB4 and monocytic U937 cells. 5- aminoimidazole-4-carboxamide ribonucleoside (AICAR), an AMPK activator, enhances ATRA-mediated differentiation of NB4 cells. In U937 cells, AICAR alone induces the expression of cell surface markers associated with mature monocytes and macrophages. In both cell lines, AICAR increases the activity of mitogen-activated protein kinase (MAPK), and the presence of a MAPK inhibitor reduces the expression of differentiation markers. These results revealed beneficial effects of AICAR in AML, including differentiation of non-APL AML cells.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Projekti:
108-1081347-0173 - Funkcija fosfoinozitol 3-kinaze C2 beta u staničnim jezgrama (Banfić, Hrvoje, MZOS ) ( CroRIS)
108-1081347-1448 - Uloga PLC i Akt u staničnom ciklusu i diferencijaciji leukemija (Višnjić, Dora, MZOS ) ( CroRIS)
Ustanove:
Medicinski fakultet, Zagreb
Profili:
Vilma Dembitz
(autor)
Hrvoje Banfić
(autor)
Hrvoje Lalić
(autor)
Vesna Lukinović-Škudar
(autor)
Dora Višnjić
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE