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Pregled bibliografske jedinice broj: 673223

Comparison of sensitivity and specificity of MAS and HLH diagnostic guidelines in 362 children with MAS complicating systemic JIA


Davì, Sergio; Minoia, Francesca; Horne, Anna Carin; Demirkaya, Erkan; Ilowite, Norman; Insalaco , Antonella; Ioseliani, Maka; Jelušić-Dražić , Marija; Kapović, Agneza Marija; Kasapcopur, Ozgur et al.
Comparison of sensitivity and specificity of MAS and HLH diagnostic guidelines in 362 children with MAS complicating systemic JIA // European Paediatric Rheumatology 20th Congress
Ljubljana, Slovenija, 2013. (poster, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 673223 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Comparison of sensitivity and specificity of MAS and HLH diagnostic guidelines in 362 children with MAS complicating systemic JIA

Autori
Davì, Sergio ; Minoia, Francesca ; Horne, Anna Carin ; Demirkaya, Erkan ; Ilowite, Norman ; Insalaco , Antonella ; Ioseliani, Maka ; Jelušić-Dražić , Marija ; Kapović, Agneza Marija ; Kasapcopur, Ozgur ; Kone-Paut, Isabelle ; Lepore, Loredana ; Li, Caifeng ; Magni-Manzoni, Silvia ; Maritsi, Despoina ; McCurdy, Deborah ; Merino, Rosa ; Miettunen, Paivi ; Ruperto, Nicolino ; Martini, Alberto ; Cron, Randy ; Ravelli, Angelo

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
European Paediatric Rheumatology 20th Congress

Mjesto i datum
Ljubljana, Slovenija, 25.09.2013. - 29.09.2013

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
sensitivity; specificity; diagnostic guidelines; macrophage activation syndrome; juvenile idiopathic arthritis; systemic;

Sažetak
Introduction: Early diagnosis of macrophage activations syndrome (MAS) in systemic juvenile idiopathic arthritis (sJIA) may be challenging because it may mimic the clinical features of the underlying disease or be confused with an infectious complication. However, the diagnostic value of the guidelines for hemophagocytic lymphohistiocytosis (HLH) or sJIA-associated MAS has seldom been examined. Objectives: To investigate the sensitivity and specificity of diagnostic guidelines for HLH and sJIA-associated MAS in patients with sJIA who developed MAS. Methods: The study sample included 362 children with sJIA who had MAS (diagnosed and treated as such by the attending physician) and 2 control groups with potentially “confusable” conditions, including active sJIA without MAS (n=404) and a systemic febrile infection requiring hospitalization (n=345). Diagnostic guidelines for HLH and sJIA-associated MAS were applied to all MAS and control patients. Because no patient had NK-cell activity and soluble CD25 determination available and bone marrow aspirate was performed in only a few patients, these 3 criteria were excluded from HLH guidelines. HLH criteria were, therefore, met when at least 4 of the 5 remaining variables were present. sJIA-associated MAS criteria were met when at least 2 laboratory criteria or at least 1 laboratory criterion and 1 clinical criterion were present. Sensitivity and specificity of guidelines in discriminating patients with MAS from control patients were assessed. Results: The table shows the comparison of sensitivity and specificity of diagnostic guidelines. Conclusion: The diagnostic guidelines for sJIA-associated MAS revealed strong sensitivity and specificity, whereas HLH guidelines were highly specific, but lacked sensitivity. Sensitivity of HLH was mostly hampered by the excessive stringent threshold for cytopenia and hypofibrinogenemia, and the infrequent occurrence of splenomegaly in patients with MAS.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
072-1080229-0337 - Modulacija funkcije ljudskih regulacijskih T-limfocita (Gagro, Alenka, MZOS ) ( CroRIS)

Ustanove:
Klinika za dječje bolesti Medicinskog fakulteta,
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb

Profili:

Avatar Url Agneza Marija Pasini (autor)

Avatar Url Marija Jelušić (autor)

Citiraj ovu publikaciju:

Davì, Sergio; Minoia, Francesca; Horne, Anna Carin; Demirkaya, Erkan; Ilowite, Norman; Insalaco , Antonella; Ioseliani, Maka; Jelušić-Dražić , Marija; Kapović, Agneza Marija; Kasapcopur, Ozgur et al.
Comparison of sensitivity and specificity of MAS and HLH diagnostic guidelines in 362 children with MAS complicating systemic JIA // European Paediatric Rheumatology 20th Congress
Ljubljana, Slovenija, 2013. (poster, međunarodna recenzija, sažetak, znanstveni)
Davì, S., Minoia, F., Horne, A., Demirkaya, E., Ilowite, N., Insalaco , A., Ioseliani, M., Jelušić-Dražić , M., Kapović, A. & Kasapcopur, O. (2013) Comparison of sensitivity and specificity of MAS and HLH diagnostic guidelines in 362 children with MAS complicating systemic JIA. U: European Paediatric Rheumatology 20th Congress.
@article{article, author = {Dav\`{\i}, Sergio and Minoia, Francesca and Horne, Anna Carin and Demirkaya, Erkan and Ilowite, Norman and Insalaco, Antonella and Ioseliani, Maka and Jelu\v{s}i\'{c}-Dra\v{z}i\'{c}, Marija and Kapovi\'{c}, Agneza Marija and Kasapcopur, Ozgur and Kone-Paut, Isabelle and Lepore, Loredana and Li, Caifeng and Magni-Manzoni, Silvia and Maritsi, Despoina and McCurdy, Deborah and Merino, Rosa and Miettunen, Paivi and Ruperto, Nicolino and Martini, Alberto and Cron, Randy and Ravelli, Angelo}, year = {2013}, keywords = {sensitivity, specificity, diagnostic guidelines, macrophage activation syndrome, juvenile idiopathic arthritis, systemic, }, title = {Comparison of sensitivity and specificity of MAS and HLH diagnostic guidelines in 362 children with MAS complicating systemic JIA}, keyword = {sensitivity, specificity, diagnostic guidelines, macrophage activation syndrome, juvenile idiopathic arthritis, systemic, }, publisherplace = {Ljubljana, Slovenija} }
@article{article, author = {Dav\`{\i}, Sergio and Minoia, Francesca and Horne, Anna Carin and Demirkaya, Erkan and Ilowite, Norman and Insalaco, Antonella and Ioseliani, Maka and Jelu\v{s}i\'{c}-Dra\v{z}i\'{c}, Marija and Kapovi\'{c}, Agneza Marija and Kasapcopur, Ozgur and Kone-Paut, Isabelle and Lepore, Loredana and Li, Caifeng and Magni-Manzoni, Silvia and Maritsi, Despoina and McCurdy, Deborah and Merino, Rosa and Miettunen, Paivi and Ruperto, Nicolino and Martini, Alberto and Cron, Randy and Ravelli, Angelo}, year = {2013}, keywords = {sensitivity, specificity, diagnostic guidelines, macrophage activation syndrome, juvenile idiopathic arthritis, systemic, }, title = {Comparison of sensitivity and specificity of MAS and HLH diagnostic guidelines in 362 children with MAS complicating systemic JIA}, keyword = {sensitivity, specificity, diagnostic guidelines, macrophage activation syndrome, juvenile idiopathic arthritis, systemic, }, publisherplace = {Ljubljana, Slovenija} }




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