Pregled bibliografske jedinice broj: 672812
Intensive Chemotherapy for Childhood Acute Lymphoblastic Leukemia : Results of the Randomized Intercontinental Trial ALL IC-BFM 2002
Intensive Chemotherapy for Childhood Acute Lymphoblastic Leukemia : Results of the Randomized Intercontinental Trial ALL IC-BFM 2002 // Journal of clinical oncology, 32 (2014), 3; 174-1 doi:10.1200/JCO.2013.48.6522 (međunarodna recenzija, članak, znanstveni)
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Naslov
Intensive Chemotherapy for Childhood Acute Lymphoblastic Leukemia : Results of the Randomized Intercontinental Trial ALL IC-BFM 2002
Autori
Stary, Jan ; Zimmermann, Martin ; Konja, Josip ; Campbell, Myriam ; Castillo, Luis ; Dibar, Eduardo ; Donska, Svetlana ; Gonzalez, Alejandro ; Izraeli, Shai ; Janic, Dragana ; Jazbec, Janez ; Kaiserova, Emilia ; Kowalczyk, Jerzy ; Kovacs, Gabor ; Li, Chi-Kong ; Magyarosy, Edina ; Popa, Alexander ; Stark, Batia ; Jabali, Yahia ; Trka, Jan ; Hrusak, Ondrej ; Riehm, Hansjörg ; Masera, GiuseppE ; Schrappe, Martin
Izvornik
Journal of clinical oncology (0732-183X) 32
(2014), 3;
174-1
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
lymhoblastic leukemia; children; chemotherapy
Sažetak
Purpose From 2002 to 2007, the International Berlin-Frankfurt-Münster Study Group conducted a prospective randomized clinical trial (ALL IC-BFM 2002) for the management of childhood acute lymphoblastic leukemia (ALL) in 15 countries on three continents. The aim of this trial was to explore the impact of differential delayed intensification (DI) on outcome in all risk groups. Patients and Methods For this trial, 5, 060 eligible patients were divided into three risk groups according to age, WBC, early treatment response, and unfavorable genetic aberrations. DI was randomized as follows: standard risk (SR), two 4-week intensive elements (protocol III) versus one 7-week protocol II ; intermediate risk (IR), protocol III × 3 versus protocol II × 1 ; high risk (HR), protocol III × 3 versus either protocol II × 2 (Associazione Italiana Ematologia Oncologia Pediatrica [AIEOP] option), or 3 HR blocks plus single protocol II (Berlin-Frankfurt-Münster [BFM] option). Results At 5 years, the probabilities of event-free survival and survival were 74% (± 1%) and 82% (± 1%) for all 5, 060 eligible patients, 81% and 90% for the SR (n = 1, 564), 75% and 83% for the IR (n = 2, 650), and 55% and 62% for the HR (n = 846) groups, respectively. No improvement was accomplished by more intense and/or prolonged DI. Conclusion The ALL IC-BFM 2002 trial is a good example of international collaboration in pediatric oncology. A wide platform of countries able to run randomized studies in ALL has been established. Although the alternative DI did not improve outcome compared with standard treatment and the overall results are worse than those achieved by longer established leukemia groups, the national results have generally improved.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
POVEZANOST RADA
Projekti:
108-0000000-0049 - Zloćudne bolesti u djece (Konja, Josip, MZOS ) ( CroRIS)
Ustanove:
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb
Profili:
Josip Konja
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
Uključenost u ostale bibliografske baze podataka::
- EMBASE (Excerpta Medica)