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Pregled bibliografske jedinice broj: 672812

Intensive Chemotherapy for Childhood Acute Lymphoblastic Leukemia : Results of the Randomized Intercontinental Trial ALL IC-BFM 2002


Stary, Jan; Zimmermann, Martin; Konja, Josip; Campbell, Myriam; Castillo, Luis; Dibar, Eduardo; Donska, Svetlana; Gonzalez, Alejandro; Izraeli, Shai; Janic, Dragana et al.
Intensive Chemotherapy for Childhood Acute Lymphoblastic Leukemia : Results of the Randomized Intercontinental Trial ALL IC-BFM 2002 // Journal of clinical oncology, 32 (2014), 3; 174-1 doi:10.1200/JCO.2013.48.6522 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 672812 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Intensive Chemotherapy for Childhood Acute Lymphoblastic Leukemia : Results of the Randomized Intercontinental Trial ALL IC-BFM 2002

Autori
Stary, Jan ; Zimmermann, Martin ; Konja, Josip ; Campbell, Myriam ; Castillo, Luis ; Dibar, Eduardo ; Donska, Svetlana ; Gonzalez, Alejandro ; Izraeli, Shai ; Janic, Dragana ; Jazbec, Janez ; Kaiserova, Emilia ; Kowalczyk, Jerzy ; Kovacs, Gabor ; Li, Chi-Kong ; Magyarosy, Edina ; Popa, Alexander ; Stark, Batia ; Jabali, Yahia ; Trka, Jan ; Hrusak, Ondrej ; Riehm, Hansjörg ; Masera, GiuseppE ; Schrappe, Martin

Izvornik
Journal of clinical oncology (0732-183X) 32 (2014), 3; 174-1

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
lymhoblastic leukemia; children; chemotherapy

Sažetak
Purpose From 2002 to 2007, the International Berlin-Frankfurt-Münster Study Group conducted a prospective randomized clinical trial (ALL IC-BFM 2002) for the management of childhood acute lymphoblastic leukemia (ALL) in 15 countries on three continents. The aim of this trial was to explore the impact of differential delayed intensification (DI) on outcome in all risk groups. Patients and Methods For this trial, 5, 060 eligible patients were divided into three risk groups according to age, WBC, early treatment response, and unfavorable genetic aberrations. DI was randomized as follows: standard risk (SR), two 4-week intensive elements (protocol III) versus one 7-week protocol II ; intermediate risk (IR), protocol III × 3 versus protocol II × 1 ; high risk (HR), protocol III × 3 versus either protocol II × 2 (Associazione Italiana Ematologia Oncologia Pediatrica [AIEOP] option), or 3 HR blocks plus single protocol II (Berlin-Frankfurt-Münster [BFM] option). Results At 5 years, the probabilities of event-free survival and survival were 74% (± 1%) and 82% (± 1%) for all 5, 060 eligible patients, 81% and 90% for the SR (n = 1, 564), 75% and 83% for the IR (n = 2, 650), and 55% and 62% for the HR (n = 846) groups, respectively. No improvement was accomplished by more intense and/or prolonged DI. Conclusion The ALL IC-BFM 2002 trial is a good example of international collaboration in pediatric oncology. A wide platform of countries able to run randomized studies in ALL has been established. Although the alternative DI did not improve outcome compared with standard treatment and the overall results are worse than those achieved by longer established leukemia groups, the national results have generally improved.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
108-0000000-0049 - Zloćudne bolesti u djece (Konja, Josip, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb

Profili:

Avatar Url Josip Konja (autor)

Poveznice na cjeloviti tekst rada:

doi dx.doi.org

Citiraj ovu publikaciju:

Stary, Jan; Zimmermann, Martin; Konja, Josip; Campbell, Myriam; Castillo, Luis; Dibar, Eduardo; Donska, Svetlana; Gonzalez, Alejandro; Izraeli, Shai; Janic, Dragana et al.
Intensive Chemotherapy for Childhood Acute Lymphoblastic Leukemia : Results of the Randomized Intercontinental Trial ALL IC-BFM 2002 // Journal of clinical oncology, 32 (2014), 3; 174-1 doi:10.1200/JCO.2013.48.6522 (međunarodna recenzija, članak, znanstveni)
Stary, J., Zimmermann, M., Konja, J., Campbell, M., Castillo, L., Dibar, E., Donska, S., Gonzalez, A., Izraeli, S. & Janic, D. (2014) Intensive Chemotherapy for Childhood Acute Lymphoblastic Leukemia : Results of the Randomized Intercontinental Trial ALL IC-BFM 2002. Journal of clinical oncology, 32 (3), 174-1 doi:10.1200/JCO.2013.48.6522.
@article{article, author = {Stary, Jan and Zimmermann, Martin and Konja, Josip and Campbell, Myriam and Castillo, Luis and Dibar, Eduardo and Donska, Svetlana and Gonzalez, Alejandro and Izraeli, Shai and Janic, Dragana and Jazbec, Janez and Kaiserova, Emilia and Kowalczyk, Jerzy and Kovacs, Gabor and Li, Chi-Kong and Magyarosy, Edina and Popa, Alexander and Stark, Batia and Jabali, Yahia and Trka, Jan and Hrusak, Ondrej and Riehm, Hansj\"{o}rg and Masera, GiuseppE and Schrappe, Martin}, year = {2014}, pages = {174-1-174-}, DOI = {10.1200/JCO.2013.48.6522}, keywords = {lymhoblastic leukemia, children, chemotherapy}, journal = {Journal of clinical oncology}, doi = {10.1200/JCO.2013.48.6522}, volume = {32}, number = {3}, issn = {0732-183X}, title = {Intensive Chemotherapy for Childhood Acute Lymphoblastic Leukemia : Results of the Randomized Intercontinental Trial ALL IC-BFM 2002}, keyword = {lymhoblastic leukemia, children, chemotherapy} }
@article{article, author = {Stary, Jan and Zimmermann, Martin and Konja, Josip and Campbell, Myriam and Castillo, Luis and Dibar, Eduardo and Donska, Svetlana and Gonzalez, Alejandro and Izraeli, Shai and Janic, Dragana and Jazbec, Janez and Kaiserova, Emilia and Kowalczyk, Jerzy and Kovacs, Gabor and Li, Chi-Kong and Magyarosy, Edina and Popa, Alexander and Stark, Batia and Jabali, Yahia and Trka, Jan and Hrusak, Ondrej and Riehm, Hansj\"{o}rg and Masera, GiuseppE and Schrappe, Martin}, year = {2014}, pages = {174-1-174-}, DOI = {10.1200/JCO.2013.48.6522}, keywords = {lymhoblastic leukemia, children, chemotherapy}, journal = {Journal of clinical oncology}, doi = {10.1200/JCO.2013.48.6522}, volume = {32}, number = {3}, issn = {0732-183X}, title = {Intensive Chemotherapy for Childhood Acute Lymphoblastic Leukemia : Results of the Randomized Intercontinental Trial ALL IC-BFM 2002}, keyword = {lymhoblastic leukemia, children, chemotherapy} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka::


  • EMBASE (Excerpta Medica)


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