Naslov
TREATMENT OUTCOME OF CHILDREN WITH HEPATOBLASTOMA

Autori
Konja, Josip ; Glavaš, Blanka ; Aničić, Mirna

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
9th Central European Oncology Congress A Best o ASCO Meeting / Sikic, I. Branimir - Opatija : Penta, 2013, 82-82

Skup
9th Central European Oncology Congress

Mjesto i datum
Opatija, Hrvatska, 13.06.2013. - 15.06.2013

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
hepatoblastoma; children; treatment

Sažetak
Background: Hepatoblastoma is the most common malignant primary tumor of the liver in children. The prognosis of hepatoblastoma in children has significantly improved over the last 20 qears. This is attrbutable to improved muultidisciplinary input including specijalist pediatric hematology-oncology and surgery. Objective To review our institutional experience with hepatoblastoma Patients and Methods: Files of children treated at our hospital between 1995-2012 with the diagnosis of hepatoblastoma were reviewed for clinical chareacteristics and treatment results. All patients presented a palpable abdominal mass. Ultrasound, CT and/or MRI were used to assess site and resectability of tumors. All patients uderwent diagnostic biopsy. 10 children (6 male and 4 female, median age at diagnosis was 2, 3/1-3, 5 y) with hepatoblastoma (3 had lung metastases) have been treated according to SIOPEL protocol with pre-operative chemotherapy, surgery and post-operativne chemotherapy. One was treated only with chemotherapy (surgery was not possible. Results: The remission has ben achieved in all patienta ; 3 pati3ents died in r3elapse. / patients are still alive in the first remission (also with lung metastases and 1 treated only with chemotherapy). Serious side effects not noticed (only 1 cardiomyopathy). Sedondary malinancies did not occur in any of patienta. Conclusion: Combined modality therapy is optimal treatment for the majority of children with heaptoblastoma. New treatment strategies using innovtive approaches are still needed to further improve tratment results.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA