Naslov
Postasphyxial renal injury in newborns as a prognostic factor of neurological outcome

Autori
Hadžimuratović, Emina ; Skrablin, Snježana ; Hadžimuratović, Admir ; Mesihović Dinarević, Senka

Izvornik
Journal of maternal-fetal & neonatal medicine (1476-7058) 27 (2014), 4; 407-410

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
postasphyxial renal injury; noenatal outcome

Sažetak
To estimate if an acute postasphyxial renal injury in newborns could indicate a neurological outcome. We conducted a prospective clinical trial on 50 full-term newborns with 5-minute Apgar score <7 (asphyxiated group) and a control group of 50 full-term newborns with 5-min Apgar score ≥7 (non-asphyxiated group). Renal function was assessed on the third day of life by serum values of creatinine, cystatin C and β2-microglobulin (β2M) and glomerular filtration rate (GFR). All newborns had brain and renal ultrasonography at early stages and were followed by Amiel-Tison Neurological Assassment (ATNA) throughout the first year of life. Mean GFR was significantly lower in asphyxiated than in non-asphyxiated group (22.08 ± 6.66 ml/min/1, 73 m2 versus 35.42 ± 2.26 ml/min/1, 73 m2 ; p < 0.001) and serum values of creatinine, cystatin C and β2M were significantly higher (1.13 versus 0.66 mg/dl ; 3.92 versus 1.52 mg/l ; 1.53 versus 0.99 mg/l ; p < 0.001). In asphyxiated group ATNA results throughout the first year of life significantly correlated with renal function (p < 0.01). A correlation of ATNA with Apgar score at 5 min, Sarnat and Sarnat staging of hypoxic ischemic encephalopathy and brain and renal ultrasonography has also been significant (p < 0.01). Our study showed a significant correlation between early impairment of renal function due to neonatal asphyxia with neurological outcome at the end of the first year of life.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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