Naslov
Bone turnover decreases 6 months after acromegaly remission but still remains higher than in healthy population

Autori
Dušek, Tina ; Kraljević, Ivana ; Škorić Polovina, Tanja ; Baretić, Maja ; Kaštelan, Darko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Endocrine Abstracts / - , 2013

Skup
15th European Congress of Endocrinology

Mjesto i datum
Kopenhagen, Danska, 27.04.2013. - 01.05.2013

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
bone turnover; acromegaly

Sažetak
Introduction: The study was designed to assess the effects of remission of acromegaly on bone turnover. Methods: Twenty-eight patients with active acromegaly (14 women ; age 48.0±9.8 years) were enrolled in the study. The control group comprised 28 age- and sex-matched healthy individuals. Bone turnover markers (osteocalcin, β-crosslaps, and bone alkaline phosphatase) were measured at enrolment and 6 months after achievement of disease remission. Transspehenoidal surgery was performed in all patients. Twenty-one patients achieved disease remission after surgery. In seven patients disease remission was achieved using somatostatin receptor analogs plus radiosurgery in two of them. Results: Patients with active acromegaly had significantly higher levels of osteocalcin (P=0.003), β-crosslaps (P<0.001) and bone alkaline phospahatase (P<0.001) than the control group. Six months after remission achievement, the patients with acromegaly had significantly lower levels of osteocalcin (P=0.003) and β-crosslaps (P=0.007) than before the treatment. Activity of bone alkaline phosphatase tended to lower, but the difference was not significant between the two measurements. No differences were found in osteocalcin level between the patients in remission and the control group (P=0.09), while the crosslaps level as well as the activity of alkaline phosphatase was still significantly higher in the acromegaly remission group (P=0.04 for both parameters). Conclusion: In patients with acromegaly, 6 months after achievement of disease remission, bone turnover significantly decreases, but still remains higher than in healthy individuals.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA