Naslov
Synthesis and biological activity of new diazenedicarboxamides as potential anticancer agents

Autori
Vajs, Jure ; Soviček, Sanja ; Kureljak, Petra ; Stojanović, NIkolina ; Steiner, Ivana ; Eljuga, Domagoj ; Urankar, Damijana ; Kočevar, Marijan ; Košmrlj, Janez ; Polanc, Slovenko ; Osmak, Maja

Izvornik
Acta chimica Slovenica (1318-0207) 60 (2013), 4; 842-852

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
diazenedicarboxamides; tumor cells; anticancer drugs

Sažetak
To increase the effectiveness of cancer treatment, more effective anti-cancer drugs, as well as the new improved strategies of cancer treatment, are urgently needed. Our previous results have shown that various diazenes are cytotoxic to different tumor cells and can even revert the resistance to cisplatin and vincristine. We also demonstrated that unsymmetrical diazenedicarboxamides 1 and 2 exhibited promising cytotoxicity. The aim of the present study was to synthesize new diazenedicarboxamides with acceptable solubility and good cytotoxicity. Here we report the synthesis and biological evaluation of new N, N’-disubstituted diazenedicarboxamides. We found that a modification of either 1 or 2 led to the more active compounds. The most effective among them was diazenedicarboxamide 11, which can be considered as a new potential anticancer agent for the tumors of different origin, as well as for the drug resistant tumors.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA