Naslov
Novel 57 kd glycoprotein in sera of humans under stress

Autori
Floegel, Mirne ; Lauc, Gordan ; Žanić-Grubišić, Tihana ; Dumić, Jerka ; Barišić, Karmela

Izvornik
Croatica Chemica Acta (0011-1643) 69 (1996), 1; 371-378

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
57 kD glycoprotein; human sera

Sažetak
Serum glycoproteins from individuals under chronic stress (prisoners of war from detention camps, n - 30) were analyzed by the Western-blot method applying a set of five different lectins (DSA, GNA, MAA, PNA and SNA). Glycoprotein patterns of samples from the stressed group revealed significant changes if compared to the control sera (from apparently non-stressed volunteers): both galactose-specific DSA lectin and sialic acid-specific SNA lectin recognized a novel nonconsitutional glycoprotein with an apparent size of 57 kDa in the stress group, which was completely absent in the control group. In addition, concentration of a 45 kDa SNA reactive glycoprotein increased more than 500 fold. The high incidence of disturbed patterns of glycoproteins in the sera of stressed subjects (95%) points to their important role in stress response and qualifies them for widespread testing as potential diagnostic markers of the stress syndrome.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

POVEZANOST RADA