Naslov
Low birth weight, cardiac shape and function and dilated cardiomyopathy – is there a connection?

Autori
Planinc, Ivo ; Bagadur, Glorija ; Ljubas, Jana ; Baricevic, Zeljko ; Skoric, Bosko ; Velagic, Vedran ; Bijnens, Bart ; Milicic, Davor ; Cikes, Maja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
European Heart Journal - Cardiovascular Imaging / - , 2013, Ii33-ii33

Skup
EUROECHO 2013

Mjesto i datum
Istanbul, Turska, 11.12.2013. - 14.12.2013

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
dilated cardiomyopathy; low birth weight

Sažetak
Purpose: Several studies link cardiovascular disease in adulthood to low birth weight (LBW). However, little is known about the relation of dilated cardiomyopathy(DCM) and LBW. LBWoccurs in 5-10% of the general population, and a lower sphericity index(SPHI) is reported in these patients(pts).We aimed to study the link betweenLBWandDCMin the pts after heart transplantation (HTx). Methods:From2009to2013 75pts underwentHTxin our institution.24ptswhoknewtheir birth weights were included in study. 8 had HTx for ischemic cardiomyopathy(ICM), 10 pts for idiopathic DCM, and 6 pts due to myocarditis. We compared birth weights(BW) between these subgroups with a cut-off for LBW set at 3000g. All pts underwent a pre-HTx full echocardiographic study from which we extracted LVIDd, LVEDV and EF from biplane measurements, as well as E/E’ and MV DecT. We calculated SPHI as LV base-to-apex length/basal diameter in the apical 4ch view. Results: AverageBWwasnotably lower in pts with (post)myocarditisandDCMcompared to ICM(Table 1.). 22% pts with DCM, 43% pts with (post)myocarditis and 14% pts with ICM had LBW. We found significant (p, 0.01) difference in BW between ICM and (post)myocarditis subgroup, as well as significant (p≤0.05) difference in LVIDd, LVEDV, E/E’ and DecT comparing DCM and ICM subgroups. SPHI was significantly lower in DCM subgroup comparing with both ICM and (post)myocarditis subgroups. Furthermore, BW was positively correlated with SPHI (r=0, 3). Conclusion: This study demonstrates a higher occurrence of LBW among DCM pts, especially (post)myocarditis pts, compared to the ICM pts or reported general population. Lower SPHI indicates a more globular LV shape and is significantly lower in our DCM pts. Correlation of LBW and SPHI indicates possible long-term effects and contribution of LBW in myocardial remodeling in adulthood. This study provides a basis for further investigation of LBW occurrence in heart failure patients, suggesting a potential role of LBW in the development of DCM or even susceptibility to myocarditis.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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