Pregled bibliografske jedinice broj: 667255
Diffuse skin hyperpigmentation in CD30+ lymphoproliferation
Diffuse skin hyperpigmentation in CD30+ lymphoproliferation // Annals of Saudi medicine, 32 (2012), 3; 318-320 doi:10.5144/0256-4947.2012.318 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 667255 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Diffuse skin hyperpigmentation in CD30+ lymphoproliferation
Autori
Prka, Željko ; Tomasović-Lončarić, Čedna ; Pejša, Vlatko ; Nevajda, Branimir ; Kušec, Rajko
Izvornik
Annals of Saudi medicine (0256-4947) 32
(2012), 3;
318-320
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
lymphoprolliferation ; skin pigmentation ; CD30
Sažetak
CD30+ T-cell lymphoproliferative disorders (LD) comprise two main groups of diseases: CD30+ LD of the skin and systemic anaplastic large cell lymphoma (ALCL). The main feature of these disorders is the expression of CD30. We present a patient with an unusual clinical presentation of CD30+ lymphoproliferative disease in a 54-year old Caucasian male who presented with generalized lymphadenopathy and pronounced skin hyperpigmentation. In the lymph nodes and skin, CD30+ lymphoproliferation (ALCL) was diagnosed. The Prussian blue staining identified that the pigment responsible for the skin color was hemosiderin. Chemotherapy was started but the patient's condition progressively worsened and he died a week after the first cycle. The complete color transformation of the entire skin due to hemosiderin accumulation is, to the best of our knowledge, the first reported observation in a CD30+ lymphoproliferation/ALCL patient. We speculate that hemosiderin-loaded macrophages resulted from the paraneoplastic process by some still unknown mechanism.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
POVEZANOST RADA
Projekti:
108-1980955-3094 - Genetika i funkcija hematopoeze i mikrookoliša Ph- mijeloproliferativnih bolesti (Kušec, Rajko, MZOS ) ( CroRIS)
198-1980955-0953 - Imunobiologija kronične B-limfocitne leukemije i mikrookoliš (Jakšić, Ozren, MZOS ) ( CroRIS)
198-1980955-0954 - Novi klinički pristupi kroničnim mijelo i limfoproliferacijama (Pejša, Vlatko, MZOS ) ( CroRIS)
Ustanove:
Medicinski fakultet, Zagreb,
Klinička bolnica "Dubrava"
Profili:
Vlatko Pejša
(autor)
Čedna Tomasović-Lončarić
(autor)
Rajko Kušec
(autor)
Željko Prka
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE