Pregled bibliografske jedinice broj: 666561
Regional differences in dendritic morphology and spine density of striatal medium spiny neurons in Foxp2 mice
Regional differences in dendritic morphology and spine density of striatal medium spiny neurons in Foxp2 mice // FENS Featured Regional Meeting Abstract Book
Prag, 2013. str. 231-231 (poster, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 666561 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Regional differences in dendritic morphology and spine density of striatal medium spiny neurons in Foxp2 mice
Autori
Bicanic, Ivana ; Bornschein, Ulrich ; Enard, Wolfgang ; Hevers, Wulf, Paabo, Svante ; Petanjek, Zdravko
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
FENS Featured Regional Meeting Abstract Book
/ - Prag, 2013, 231-231
ISBN
978-80-260-4881-7
Skup
FENS Featured Regional Meeting 2013
Mjesto i datum
Prag, Češka Republika, 11.09.2013. - 14.09.2013
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
speech development; cortico-striatal circuitry; GABA; glutamate; dopamine
Sažetak
The extent of language capability sets humans apart from their closest living relatives, the chimpanzees. The transcription factor FOXP2 (Forkhead box protein P2), which is required for speech and language development, carries two amino acid substitutions (T303N, N325S) on the hominine lineage which were likely positively selected during human evolution. When the human variant of the FOXP2 protein is expressed in mice (Enard et al, Cell 137:861, 2009), these animals show an increased dendritic complexity of neurons that are a part of the basal ganglia circuitry and highly express FOXP2, e.g. striatal medium spiny neurons (MSN) (Reimers-Kipping et al, Neuroscience 175:75, 2011). Here, we analyze regional differences in dendritic morphology and spine density of Golgi-Cox impregnated MSN in mice homozygous for the Foxp2 human variant and in two additional mouse strains where one carries only the threonine-to-asparagine substitution at position 302 (T302N ; N303 in humans) while the other carries the asparagine-to-serine at position 324 (N324S ; S325 in humans) in their endogenous Foxp2 gene. Differences in dendritic morphology and spine density appear to be most pronounced in mice expressing the FOXP2 variant with the T302N substitution which is - in contrast to the N324S mutation – uniquely found in humans.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Projekti:
108-1081870-1932 - PUTEVI MIGRACIJE HIPOKAMPALNIH GABA-ergičkih NEURONA U MAJMUNA I ČOVJEKA (Petanjek, Zdravko, MZOS ) ( CroRIS)
Ustanove:
Medicinski fakultet, Zagreb
