Pregled bibliografske jedinice broj: 666072
Survival rates and prognostic features of 1167 papillary thyroid carcinoma patients with long- term follow up
Survival rates and prognostic features of 1167 papillary thyroid carcinoma patients with long- term follow up // European Thyroid Journal
Liblice, Češka Republika: Karger Publishers, 2013. str. 123-123 (poster, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 666072 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Survival rates and prognostic features of 1167 papillary thyroid carcinoma patients with long- term follow up
Autori
Jukić, Tomislav ; Franceschi, Maja ; Lukinac, Ljerka ; Granić, Roko ; Staničić, Josip ; Šiško Markoš, Ines ; Punda, Marija ; Dabelić, Nina ; Mateša, Neven ; Sonicki, Zdenko ; Kusić, Zvonko
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
European Thyroid Journal
/ - : Karger Publishers, 2013, 123-123
ISBN
978-3-318-02521-7
Skup
37th Annual Meeting of the European Thyroid Association
Mjesto i datum
Liblice, Češka Republika, 07.09.2013. - 11.09.2013
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
Papillary thyroid cancer; follow-up
Sažetak
Objectives: The aim of the study was to assess survival rates and prognostic features affecting outcome of papillary thyroid carcinoma (PTC) patients (pts) treated and followed-up in one institution. A total of 1167 PTC pts (F:M ratio 4:1) operated between 1970–2009 with a mean follow-up 8.4 years (y) (range 0.5–41y) were included in the study. Median pts age at the time of diagnosis was 47y (6–83y). All pts underwent total/near total thyroidectomy and 95% pts underwent 131-I treatment. Median tumor size (MTS) was 12mm (1–100mm). Methods: Prognostic factors: age (<45y, >45y), gender, tumor size (<40mm, >40mm), presence of local and distant metastases at the time of diagnosis were evaluated with univariate (Kaplan- Meier Survival Curves, Log- rank test) and multivariate analysis (Cox Regression) (p < 0.05). Results: Local metastases were recorded in 252(27%) pts at initial presentation. Loco- regional recurrence developed in 59(5%) pts during follow-up. Distant metastases were recorded in 40(3.4%) pts at initial presentation (F:M ratio 1.3:1, MTS 33mm) and developed subsequently in 3 pts. Lung and bone metastases were the most frequent. 14 PTC pts died from disease (8 with distant meta and 6 with inoperable advanced loco- regional disease) (F:M ratio 0.6:1, MTS 45mm). Overall 5 and 10-year cancer-specific survival rate in PTC pts was 99.1% and 98.8% (80% with distant metastases). Univariate analysis demonstrated older age, male gender, larger tumor size, presence of local and distant metastases at the time of diagnosis as significant (p < 0.001) features affecting outcome. Multivariate analysis demonstrated older age (p = 0.05), larger tumor size (p = 0.01) and distant metastases (p < 0.001) as prognostic features affecting outcome. Conclusions: PTCs are malignant tumors with extremely low mortality. Distant metastases are rare and can be successfully treated. Older age, larger tumor size and presence of distant metastases are independent, negative prognostic factors that influence outcome of PTC patients.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
POVEZANOST RADA
Projekti:
134-1342428-2430 - Karcinogeneza u štitnjači i gušavost u Hrvatskoj (Kusić, Zvonko, MZOS ) ( CroRIS)
Ustanove:
KBC "Sestre Milosrdnice"
Profili:
Ljerka Lukinac
(autor)
Josip Staničić
(autor)
Tomislav Jukić
(autor)
Neven Mateša
(autor)
Roko Granić
(autor)
Maja Franceschi
(autor)
Zvonko Kusić
(autor)
Zdenko Sonicki
(autor)
INES ŠIŠKO MARKOŠ
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Emerging Sources Citation Index (ESCI)