Naslov
Važnost mehanizma multiksenobiotičke otpornosti (MXR) u akvakulturi
(Importance of multixenobiotic resistance (MXR) mechanism in aquaculture)

Autori
Sauerborn Klobučar, Roberta ; Malev, Olga ; Barišić, Josip ; Topić Popović, Natalija ; Strunjak-Perović, Ivančica ; Margita, Jadan ; Čož-Rakovac, Rozelinda.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
9. međunarodni gospodarsko-znanstveni skup o ribarstvu "Hrvatska akvakultura u Europskoj uniji - sadašnjost i budućnost" : knjiga sažetaka / - , 2013

Skup
Međunarodni gospodarsko-znanstveni skup o ribarstvu "Hrvatska akvakultura u Europskoj uniji - sadašnjost i budućnost" (9 ; 2013)

Mjesto i datum
Vukovar, Hrvatska, 2013

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
akvakultura; MXR mehanizam; ABC transportni proteini
(multixenobiotic resistance mechanism (MXR); bivalves; fish; aquatic amphipod; MRP; P-glycoprotein (Pgp); ABC-transport proteins)

Sažetak
One of the most intriguing cellular defence strategies evolutionary developed in aquatic organisms is the activity of the multixenobiotic resistance (MXR) mechanism first described in early 1990s. Analogous to the well-known multidrug resistant (MDR) mechanism discovered in tumour cells, MXR in aquatic organisms is mediated by expression of the same transmembrane ATP-dependent proteins (ABC proteins). MDR/MXR results from the rapid efflux of a wide variety of potentially toxic xenobiotics out of the cell. The best-studied ABC protein in aquatic organisms is the P-glycoprotein (ABCB1), while recent studies demonstrate the importance of other types of transport proteins such as MRP (ABCC) and the presence of the MRP-related genes in fish and mussels. The main goal of this study was the detection of ABCC (MRP) related gene sequences and functional detection of Pgp and MRP-like transport activities in aquatic animals. These new findings should help in better characterization and identification of all proteins possibly involved in MXR phenomenon and will influence afirmation of these biomarker in evaluation of environmental quality, especially in aquaculture.

Izvorni jezik
Engleski

Znanstvena područja
Veterinarska medicina

Napomena
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