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Pregled bibliografske jedinice broj: 665137

Single nucleotide polymorphism in the STAT3 gene may influence susceptibility to UC and CD in a Croatian population


Mihaljević, Silvio; Smolić, Robert; Štefanić, Mario; Krznarić, Željko; Glavaš-Obrovac, Ljubica; Takač, Boris; Kibel, Aleksandar
Single nucleotide polymorphism in the STAT3 gene may influence susceptibility to UC and CD in a Croatian population // Asian Pacific Digestive Week 2013 and World Congress of Gastroenterology (Gastro 2013 APDW/WCOG) : abstracts ; u: Journal of Gastroenterology and Hepatology 28 (2013)(S3) ; Poster presentation 23-693 ; P1479
Šangaj, Kina: John Wiley & Sons, 2013. str. 581-581 (poster, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 665137 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Single nucleotide polymorphism in the STAT3 gene may influence susceptibility to UC and CD in a Croatian population

Autori
Mihaljević, Silvio ; Smolić, Robert ; Štefanić, Mario ; Krznarić, Željko ; Glavaš-Obrovac, Ljubica ; Takač, Boris ; Kibel, Aleksandar

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Asian Pacific Digestive Week 2013 and World Congress of Gastroenterology (Gastro 2013 APDW/WCOG) : abstracts ; u: Journal of Gastroenterology and Hepatology 28 (2013)(S3) ; Poster presentation 23-693 ; P1479 / - : John Wiley & Sons, 2013, 581-581

Skup
Asian Pacific Digestive Week 2013 – World Congress of Gastroenterology

Mjesto i datum
Šangaj, Kina, 21.09.2013. - 24.09.2013

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
STAT3; gene; polymorphism; inflammatory bowel disease; Croatia

Sažetak
The Signal Transducers and Activators of Transcription(STATS) are intracellular effector molecules of cytokine-modulated signalling, which play important role in the development of the human immune system and haematopoiesis, and are involved in the regulation of T-cell survival. STAT3, a master regulator of Th17 and FoxP3+Treg polarization, was recently associated with increased risk of ulcerative colitis (UC) and Chron’s disease (CD). Aim was to investigate whether a functional single nucleotide polymorphism (SNP) in the STAT3 gene is likely to be important for UC and CD risk in a Croatian population, and whether its phenotypic relationship could provide useful clinical predictions. A total of 50 CD patients and 91 UC patients, as well as 95 healthy control subjects were included in the study. The intronic variant in the STAT3 gene (GenBank: NM 213662, rs744166) was genotyped using fluorescence resonance energy transfer technology and melting curve analysis of polymerase chain reaction products. The observed population allele frequencies in the controls were similar to those reported in other Caucasian populations (36.8%, G allele). No significant difference was observed in genotype and allele frequencies between the cases and controls (CD: odds ratio 1.29, 95% confidence interval 0.78–2.11, P = 0.322 ; UC: 0.86 (0.56–1.32), P = 0.502, allelic contrasts, G allele). No further associations were uncovered by inspection of secondary traits. Here, we have demonstrated that the STAT3 rs744166 variant is not associated with CD, UC susceptibility or disease severity in the Croatian population, but pathogenetic mechanisms remain to be further evaluated. The STAT signalling pathway remains a potential therapeutic target for the development of new treatment options for UC and CD.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

Napomena
DOI: 10.1111/jgh.12363_2



POVEZANOST RADA


Projekti:
108-0000000-3114 - HELICOBAKTER PYLORI INFEKCIJA - EVOLUCIJA BOLESTI I NOVI TERAPIJSKI POSTUPCI (Katičić, Miroslava, MZOS ) ( CroRIS)
127-0000000-3420 - Značaj genskih polimorfizama u autoimunim bolestima štitnjače (Karner, Ivan, MZOS ) ( CroRIS)
219-0982914-2176 - Mehanizam bioloških učinaka novih malih molekula na stanice tumora čovjeka (Glavaš Obrovac, Ljubica, MZOS ) ( CroRIS)
219-2190372-2068 - Polimorfizmi u genu za vitamin D receptor u psorijazi i atopijskom dermatitisu (Štefanić, Mario, MZOS ) ( CroRIS)
219-2190372-3119 - Genski polimorfizmi detoksikacijskih molekula u upalnim bolestima crijeva (Mihaljević, Silvio, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Zagreb,
Klinički bolnički centar Osijek,
Klinički bolnički centar Zagreb,
Medicinski fakultet, Osijek

Citiraj ovu publikaciju:

Mihaljević, Silvio; Smolić, Robert; Štefanić, Mario; Krznarić, Željko; Glavaš-Obrovac, Ljubica; Takač, Boris; Kibel, Aleksandar
Single nucleotide polymorphism in the STAT3 gene may influence susceptibility to UC and CD in a Croatian population // Asian Pacific Digestive Week 2013 and World Congress of Gastroenterology (Gastro 2013 APDW/WCOG) : abstracts ; u: Journal of Gastroenterology and Hepatology 28 (2013)(S3) ; Poster presentation 23-693 ; P1479
Šangaj, Kina: John Wiley & Sons, 2013. str. 581-581 (poster, međunarodna recenzija, sažetak, znanstveni)
Mihaljević, S., Smolić, R., Štefanić, M., Krznarić, Ž., Glavaš-Obrovac, L., Takač, B. & Kibel, A. (2013) Single nucleotide polymorphism in the STAT3 gene may influence susceptibility to UC and CD in a Croatian population. U: Asian Pacific Digestive Week 2013 and World Congress of Gastroenterology (Gastro 2013 APDW/WCOG) : abstracts ; u: Journal of Gastroenterology and Hepatology 28 (2013)(S3) ; Poster presentation 23-693 ; P1479.
@article{article, author = {Mihaljevi\'{c}, Silvio and Smoli\'{c}, Robert and \v{S}tefani\'{c}, Mario and Krznari\'{c}, \v{Z}eljko and Glava\v{s}-Obrovac, Ljubica and Taka\v{c}, Boris and Kibel, Aleksandar}, year = {2013}, pages = {581-581}, keywords = {STAT3, gene, polymorphism, inflammatory bowel disease, Croatia}, title = {Single nucleotide polymorphism in the STAT3 gene may influence susceptibility to UC and CD in a Croatian population}, keyword = {STAT3, gene, polymorphism, inflammatory bowel disease, Croatia}, publisher = {John Wiley and Sons}, publisherplace = {\v{S}angaj, Kina} }
@article{article, author = {Mihaljevi\'{c}, Silvio and Smoli\'{c}, Robert and \v{S}tefani\'{c}, Mario and Krznari\'{c}, \v{Z}eljko and Glava\v{s}-Obrovac, Ljubica and Taka\v{c}, Boris and Kibel, Aleksandar}, year = {2013}, pages = {581-581}, keywords = {STAT3, gene, polymorphism, inflammatory bowel disease, Croatia}, title = {Single nucleotide polymorphism in the STAT3 gene may influence susceptibility to UC and CD in a Croatian population}, keyword = {STAT3, gene, polymorphism, inflammatory bowel disease, Croatia}, publisher = {John Wiley and Sons}, publisherplace = {\v{S}angaj, Kina} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





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