Pregled bibliografske jedinice broj: 665040
Increased frequency of micronuclei in mononucleated lymphocytes and cytome analysis in healthy newborns as an early warning biomarkers of possible future health risks
Increased frequency of micronuclei in mononucleated lymphocytes and cytome analysis in healthy newborns as an early warning biomarkers of possible future health risks // Reproductive toxicology, 42 (2013), 110-115 doi:10.1016/j.reprotox.2013.08.004 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 665040 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Increased frequency of micronuclei in mononucleated lymphocytes and cytome analysis in healthy newborns as an early warning biomarkers of possible future health risks
Autori
Fučić, Aleksandra ; Katić, Jelena ; Fthenou, Eleni ; Kogevinas, Manolis ; Plavec, Davor ; Koppe, Jana ; Batinić, Drago ; Chalkiadaki, Georgia ; Chatzi, Leda ; Lasan, Ružica ; Kleinjans, Jos ; Kirsch- Volders, Micheline
Izvornik
Reproductive toxicology (0890-6238) 42
(2013);
110-115
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
newborn; micronucleus assay; binuclear lymphocyte; mononuclear lymphocyte; mother; nuclear division index; C-FISH
Sažetak
Impact of intrauterine development on health risks during adolescence and adulthood still needs to be investigated. The aim of study was to compare genome damage in newborns and mothers using the cytokinesis blocked micronucleus assay, nuclear division index (NDI), and centromere fluorescence in situ hybridization. The study was performed on 92 mothers and their newborns. Results showed that micronucleus frequency in binuclear T-lymphocytes (MNBN) in newborns was significantly lower than in mothers but higher in mononuclear T-lymphocytes (MNMONO). The NDI in the mothers was significantly higher than in the newborns. In newborns with <2500 g birth weight, NDI was similar to the mothers’. Mothers have significantly more centromere negative micronuclei than newborns. A significantly higher NDI and MNBN was found in newborns with ≥2 MNMONO/1000 than in newborns with <2 MNMONO/1000. It is suggested that MOMN and NDI might be good candidates for biomarkers of health risks in newborns.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita
POVEZANOST RADA
Projekti:
108-0000000-0049 - Zloćudne bolesti u djece (Konja, Josip, MZOS ) ( CroRIS)
214-1081347-0355 - Uloga PI3K/Akt i MAPK u regulaciji kemorezistencije leukemijskih stanica (Batinić, Drago, MZOS ) ( CroRIS)
Ustanove:
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE