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Pregled bibliografske jedinice broj: 665040

Increased frequency of micronuclei in mononucleated lymphocytes and cytome analysis in healthy newborns as an early warning biomarkers of possible future health risks


Fučić, Aleksandra; Katić, Jelena; Fthenou, Eleni; Kogevinas, Manolis; Plavec, Davor; Koppe, Jana; Batinić, Drago; Chalkiadaki, Georgia; Chatzi, Leda; Lasan, Ružica et al.
Increased frequency of micronuclei in mononucleated lymphocytes and cytome analysis in healthy newborns as an early warning biomarkers of possible future health risks // Reproductive toxicology, 42 (2013), 110-115 doi:10.1016/j.reprotox.2013.08.004 (međunarodna recenzija, članak, znanstveni)


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Naslov
Increased frequency of micronuclei in mononucleated lymphocytes and cytome analysis in healthy newborns as an early warning biomarkers of possible future health risks

Autori
Fučić, Aleksandra ; Katić, Jelena ; Fthenou, Eleni ; Kogevinas, Manolis ; Plavec, Davor ; Koppe, Jana ; Batinić, Drago ; Chalkiadaki, Georgia ; Chatzi, Leda ; Lasan, Ružica ; Kleinjans, Jos ; Kirsch- Volders, Micheline

Izvornik
Reproductive toxicology (0890-6238) 42 (2013); 110-115

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
newborn; micronucleus assay; binuclear lymphocyte; mononuclear lymphocyte; mother; nuclear division index; C-FISH

Sažetak
Impact of intrauterine development on health risks during adolescence and adulthood still needs to be investigated. The aim of study was to compare genome damage in newborns and mothers using the cytokinesis blocked micronucleus assay, nuclear division index (NDI), and centromere fluorescence in situ hybridization. The study was performed on 92 mothers and their newborns. Results showed that micronucleus frequency in binuclear T-lymphocytes (MNBN) in newborns was significantly lower than in mothers but higher in mononuclear T-lymphocytes (MNMONO). The NDI in the mothers was significantly higher than in the newborns. In newborns with <2500 g birth weight, NDI was similar to the mothers’. Mothers have significantly more centromere negative micronuclei than newborns. A significantly higher NDI and MNBN was found in newborns with ≥2 MNMONO/1000 than in newborns with <2 MNMONO/1000. It is suggested that MOMN and NDI might be good candidates for biomarkers of health risks in newborns.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita



POVEZANOST RADA


Projekti:
108-0000000-0049 - Zloćudne bolesti u djece (Konja, Josip, MZOS ) ( CroRIS)
214-1081347-0355 - Uloga PI3K/Akt i MAPK u regulaciji kemorezistencije leukemijskih stanica (Batinić, Drago, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb

Profili:

Avatar Url Davor Plavec (autor)

Avatar Url Aleksandra Fučić (autor)

Avatar Url Drago Batinić (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com

Citiraj ovu publikaciju:

Fučić, Aleksandra; Katić, Jelena; Fthenou, Eleni; Kogevinas, Manolis; Plavec, Davor; Koppe, Jana; Batinić, Drago; Chalkiadaki, Georgia; Chatzi, Leda; Lasan, Ružica et al.
Increased frequency of micronuclei in mononucleated lymphocytes and cytome analysis in healthy newborns as an early warning biomarkers of possible future health risks // Reproductive toxicology, 42 (2013), 110-115 doi:10.1016/j.reprotox.2013.08.004 (međunarodna recenzija, članak, znanstveni)
Fučić, A., Katić, J., Fthenou, E., Kogevinas, M., Plavec, D., Koppe, J., Batinić, D., Chalkiadaki, G., Chatzi, L. & Lasan, R. (2013) Increased frequency of micronuclei in mononucleated lymphocytes and cytome analysis in healthy newborns as an early warning biomarkers of possible future health risks. Reproductive toxicology, 42, 110-115 doi:10.1016/j.reprotox.2013.08.004.
@article{article, author = {Fu\v{c}i\'{c}, Aleksandra and Kati\'{c}, Jelena and Fthenou, Eleni and Kogevinas, Manolis and Plavec, Davor and Koppe, Jana and Batini\'{c}, Drago and Chalkiadaki, Georgia and Chatzi, Leda and Lasan, Ru\v{z}ica and Kleinjans, Jos and Kirsch- Volders, Micheline}, year = {2013}, pages = {110-115}, DOI = {10.1016/j.reprotox.2013.08.004}, keywords = {newborn, micronucleus assay, binuclear lymphocyte, mononuclear lymphocyte, mother, nuclear division index, C-FISH}, journal = {Reproductive toxicology}, doi = {10.1016/j.reprotox.2013.08.004}, volume = {42}, issn = {0890-6238}, title = {Increased frequency of micronuclei in mononucleated lymphocytes and cytome analysis in healthy newborns as an early warning biomarkers of possible future health risks}, keyword = {newborn, micronucleus assay, binuclear lymphocyte, mononuclear lymphocyte, mother, nuclear division index, C-FISH} }
@article{article, author = {Fu\v{c}i\'{c}, Aleksandra and Kati\'{c}, Jelena and Fthenou, Eleni and Kogevinas, Manolis and Plavec, Davor and Koppe, Jana and Batini\'{c}, Drago and Chalkiadaki, Georgia and Chatzi, Leda and Lasan, Ru\v{z}ica and Kleinjans, Jos and Kirsch- Volders, Micheline}, year = {2013}, pages = {110-115}, DOI = {10.1016/j.reprotox.2013.08.004}, keywords = {newborn, micronucleus assay, binuclear lymphocyte, mononuclear lymphocyte, mother, nuclear division index, C-FISH}, journal = {Reproductive toxicology}, doi = {10.1016/j.reprotox.2013.08.004}, volume = {42}, issn = {0890-6238}, title = {Increased frequency of micronuclei in mononucleated lymphocytes and cytome analysis in healthy newborns as an early warning biomarkers of possible future health risks}, keyword = {newborn, micronucleus assay, binuclear lymphocyte, mononuclear lymphocyte, mother, nuclear division index, C-FISH} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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