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Pregled bibliografske jedinice broj: 664049

Molecular signatures of the three stem cell lineages in hydra and the emergence of stem cell function at the base of multicellularity

Hemmrich, G.; Khalturin, K.; Boehm, A.M.; Puchert, M.; Anton-Erxleben, F.; Wittlieb, J.; Klostermeier, U.C.; Rosenstiel, P.; Oberg H.H.; Domazet-Lošo, Tomislav et al.
Molecular signatures of the three stem cell lineages in hydra and the emergence of stem cell function at the base of multicellularity // Molecular biology and evolution, 29 (2012), 11; 3267-3280 doi:10.1093/molbev/mss134 (međunarodna recenzija, članak, znanstveni)

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Naslov
Molecular signatures of the three stem cell lineages in hydra and the emergence of stem cell function at the base of multicellularity

Autori
Hemmrich, G. ; Khalturin, K. ; Boehm, A.M. ; Puchert, M. ; Anton-Erxleben, F. ; Wittlieb, J. ; Klostermeier, U.C. ; Rosenstiel, P. ; Oberg H.H. ; Domazet-Lošo, Tomislav ; Sugimoto, T. ; Niwa, H. ; Bosch, T.C.

Izvornik
Molecular biology and evolution (0737-4038) 29 (2012), 11; 3267-3280

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
evolution; hydra; stem cell; aging; adult stem cell; self-renewal; differentiation; evolution

Sažetak
How distinct stem cell populations originate and whether there is a clear stem cell "genetic signature" remain poorly understood. Understanding the evolution of stem cells requires molecular profiling of stem cells in an animal at a basal phylogenetic position. In this study, using transgenic Hydra polyps, we reveal for each of the three stem cell populations a specific signature set of transcriptions factors and of genes playing key roles in cell type-specific function and interlineage communication. Our data show that principal functions of stem cell genes, such as maintenance of stemness and control of stem cell self-renewal and differentiation, arose very early in metazoan evolution. They are corroborating the view that stem cell types shared common, multifunctional ancestors, which achieved complexity through a stepwise segregation of function in daughter cells.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA

Projekti:
098-0982913-2832 - Evolucija i funkcija brzo evoluirajućeg dijela eukariotskog genoma (Ugarković, Đurđica, MZOS ) ( CroRIS)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Tomislav Domazet-Lošo (autor)

Poveznice na cjeloviti tekst rada:

doi mbe.oxfordjournals.org

Citiraj ovu publikaciju:

Hemmrich, G.; Khalturin, K.; Boehm, A.M.; Puchert, M.; Anton-Erxleben, F.; Wittlieb, J.; Klostermeier, U.C.; Rosenstiel, P.; Oberg H.H.; Domazet-Lošo, Tomislav et al.
Molecular signatures of the three stem cell lineages in hydra and the emergence of stem cell function at the base of multicellularity // Molecular biology and evolution, 29 (2012), 11; 3267-3280 doi:10.1093/molbev/mss134 (međunarodna recenzija, članak, znanstveni)
Hemmrich, G., Khalturin, K., Boehm, A., Puchert, M., Anton-Erxleben, F., Wittlieb, J., Klostermeier, U., Rosenstiel, P., Oberg H.H. & Domazet-Lošo, T. (2012) Molecular signatures of the three stem cell lineages in hydra and the emergence of stem cell function at the base of multicellularity. Molecular biology and evolution, 29 (11), 3267-3280 doi:10.1093/molbev/mss134.
@article{article, author = {Hemmrich, G. and Khalturin, K. and Boehm, A.M. and Puchert, M. and Anton-Erxleben, F. and Wittlieb, J. and Klostermeier, U.C. and Rosenstiel, P. and Domazet-Lo\v{s}o, Tomislav and Sugimoto, T. and Niwa, H. and Bosch, T.C.}, year = {2012}, pages = {3267-3280}, DOI = {10.1093/molbev/mss134}, keywords = {evolution, hydra, stem cell, aging, adult stem cell, self-renewal, differentiation, evolution}, journal = {Molecular biology and evolution}, doi = {10.1093/molbev/mss134}, volume = {29}, number = {11}, issn = {0737-4038}, title = {Molecular signatures of the three stem cell lineages in hydra and the emergence of stem cell function at the base of multicellularity}, keyword = {evolution, hydra, stem cell, aging, adult stem cell, self-renewal, differentiation, evolution} }
@article{article, author = {Hemmrich, G. and Khalturin, K. and Boehm, A.M. and Puchert, M. and Anton-Erxleben, F. and Wittlieb, J. and Klostermeier, U.C. and Rosenstiel, P. and Domazet-Lo\v{s}o, Tomislav and Sugimoto, T. and Niwa, H. and Bosch, T.C.}, year = {2012}, pages = {3267-3280}, DOI = {10.1093/molbev/mss134}, keywords = {evolution, hydra, stem cell, aging, adult stem cell, self-renewal, differentiation, evolution}, journal = {Molecular biology and evolution}, doi = {10.1093/molbev/mss134}, volume = {29}, number = {11}, issn = {0737-4038}, title = {Molecular signatures of the three stem cell lineages in hydra and the emergence of stem cell function at the base of multicellularity}, keyword = {evolution, hydra, stem cell, aging, adult stem cell, self-renewal, differentiation, evolution} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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