Naslov
Revealing 4-hydroxynonenal-histidine adducts as qualitative and quantitative biomarker of oxidative stress, lipid peroxidation and oxidative homeostasis

Autori
Zarkovic, Neven ; Zarkovic, Kamelija ; Milkovic, Lidija ; Andrisic, Luka ; Borovic, Suzana ; Waeg, Georg ; Weber, Daniela ; Bennett, Stuart J. ; Griffith, Helen R. ; Gune, Tilman.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
SFRR-Europe 2013 Abstracts, SFRR - Europe 2013 Meeting "The new era of -omics in Free Radicals in Biology and Medicine" / Kelvin J. A. Davies - San Antonio (TX) : Elsevier, 2013, S14-S15

Skup
SFRR - Europe 2013 Meeting "The new era of -omics in Free Radicals in Biology and Medicine"

Mjesto i datum
Atena, Grčka, 23.09.2013. - 25.09.2013

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
lipid peroxidation; biomarker; HNE-His adducts

Sažetak
Findings on growth regulating activities of the end-product of lipid peroxidation 4-hydroxy-2-nonenal (HNE), which acts as a “second messenger of free radicals”, overlapped with the development of antibodies specific for the aldehyde-protein adducts. These led to qualitative immunochemical determinations of the HNE presence in various pathophysiological processes and to the change of consideration of the aldehyde’s bioactivities from toxicity into cell signalling Moreover, findings of the HNE-protein adduct in various organs under physiological circumstances support the concept of “oxidative homeostasis”, which implies that oxidative stress and lipid peroxidation are not only pathological but also physiological processes. Reactive aldehydes, at least HNE, could play important role in oxidative homeostasis, while complementary research approaches might reveal the relevance of the aldehydic-protein adducts as major biomarkers of oxidative stress, lipid peroxidation and oxidative homeostasis. Aiming to join efforts in such research activities researchers interacting through the International 4-Hydroxynonenal Club acting within the SFRR-International and through networking projects of the system of the European Cooperation in Science and Technology (COST) carried validation of the methods for lipid peroxidation and further developed the genuine 4-HNE-His ELISA founding quantitative and qualitative methods for detection of 4-HNE-His adducts as valuable tool to study oxidative stress and lipid peroxidation in cell cultures, various organs and tissues and eventually for human plasma and serum analyses [1].

Izvorni jezik
Engleski

POVEZANOST RADA