Naslov
Attentional modulation of the M50 gating network

Autori
Josef Golubic, Sanja ; Susac, Ana ; Huonker, Ralph ; Haueisen, Jens ; Supek, Selma

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts 4th Croatian Congress of Neuroscience / / - Zagreb : Hrvatsko društvo za neuroznanost ; Hrvatski institut za istraživanje mozga Medicinskog fakulteta Sveučilišta u Zagrebu, 2013, 58-58

Skup
4th Croatian Congress of Neuroscience

Mjesto i datum
Zagreb, Hrvatska, 20.09.2013. - 21.09.2013

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
magnetoencefalografija (MEG); evocirana slušna neuromagnetska polja; prostorno-vremensko lokaliziranje; neurodinamika; slušno procesiranje; paired-click paradigma; M50 komponenta slušnog odgovora; gating out fenomen; utjecaj pažnje; prefrontalni korteks (PF); primarno slušno područje (STG)
(magnetoencephalography (MEG); evoked auditory neuromagnetic fields; auditory processing; paired-click paradigm; auditory M50 component; gating out; attentional modulation; prefrontal cortex (PF); primary auditorx cortex (STG))

Sažetak
Identification of the topology and cortical dynamics of the M50 auditory gating network may advance understanding of the neural ability to inhibit redundant information since disruption of this ability is often associated with pathological conditions. This study challenges the accepted model of the M50 gating as a pre-attentive, automatic inhibitory process by investigating whether a voluntary attention directed at the second tone of a pair could compromise the gating out phenomenon at the cortical level. We used MEG recordings (Elekta Neuromag, Oy 306-channel whole- head system) acquired in a magnetically shielded room at the Biomagnetic Center in Jena, Germany and multi-dipole CSST method for spatio-temporal source localization were used to identify the M50 cortical network evoked within a paired-click paradigm in 19 healthy younger subjects. Two consecutive (ISI=500 ms) identical short tones (S1 and S2 ; duration=20ms ; f=1200Hz ; ITI=8±1ms) were used to evoke standard gating cortical responses. Directing attention toward S2 tone was assessed by the task to respond to a non-identical second tone of the gating pair (R= 1300Hz, p (S1R) = 0.3) in the second condition. Our results indicated the activation of 3-4 brain regions in a 30-100 ms time interval evoked within a classical passive paradigm, including bilateral superior temporal gyri (STG), lateral prefrontal (LPF) and parietal (PA) regions. Targeting attention toward the second tone activated orbitofrontal (OF) region in addition to bilateral STG and enhanced the M50 amplitude of the STG responses to the repeated tone (S2). Gating out phenomenon was evident only in the dynamics of the STG sources while PA, PF and OF generators didn't suppress their responses to the repeated tone. The classical cortical gating out ratio (S2/S1) in the dynamics of the STG sources was found to be 68% lower than in the engaging attention condition. Our novel finding demonstrating an attentional modulation of the dynamics and topology of the M50 gating network suggests using controlled attention as a potentially effective approach to reduce gating out phenomenon disorders that occurs in many pathological conditions and diseases such as schizophrenia, autism or ADHD.

Izvorni jezik
Engleski

Znanstvena područja
Fizika, Temeljne medicinske znanosti, Kliničke medicinske znanosti

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