Naslov
Cross talk between the concentration of enzyme matrix metallopro teinase-9 (MMP) and immune status in atherosclerosis

Autori
Mrakovcic-Sutic, I ; Bulog, A ; Micovic, V ; Kovacevic, M ; Brekalo, Z

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

Skup
3. Congress of Croatian Physiological Society and 1. Regional Congress of the Physiological Societies

Mjesto i datum
Rijeka, Hrvatska, 13.09.2013. - 15.09.2013

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
atherosclerosis; matrix metalloproteinases; innate immunity

Sažetak
Introduction: atherosclerosis is a multifactor disease which includes inflammatory, metabolic and autoimmune components. It is a complex chronic inflammatory disease that affects arteries and is characterized by atherosclerotic plaques and phenotypic changes of vascular cells. Matrix metalloproteinases (MMPs) play a key role in the: physiology of connective tissue development, morphogenesis and wound healing. Their unregulated activity has been implicated in numerous disease processes including arthritis, tumor cell metastasis and atherosclerosis. MMPs contribute to collagen breakdown in atherosclerotic plaques. Furthermore, matrix degradation by MMPs may cause the plaque instability and rupture that leads to the clinical symptoms of atherosclerosis ; unstable angina, myocardial infarction and stroke. Patients and methods: patients were selected from a stratified population that are controlled or treated at the Department of Toracovascular Surgery in Clinical Hospital Centre Rijeka and divided in three groups: patients with symptomatic carotid artery disease, asymptomatic patients and blood donors as healthy controls. The method of enzyme immunoassay (ELISA) was used to determine enzyme expression of MMP-9. The phenotypic profiles of peripheral blood lymphocytes were done by flow cytometry. Results: patients with atherosclerosis had a statistically significantly elevated level of MMP-9 in the urine and the percentage of cells of innate immunity in peripheral blood in comparison with healthy volunteers. Innate immune cells statistically significant correlate with MMP-9 concentration. Conclusion: These results provide new evidence about the interaction of the concentration of MMP-9 in urine, the innate immunity, the degree of stenosis of the carotid arteries and the incidence of symptoms.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

POVEZANOST RADA