Naslov
Assessment of risk for public and animal health related to the presence of citrinin in food and feed

Autori
Baert, Katleen ; Scaravelli, Elena ; Böhm , Josef , De Saeger, Sarah ; Fink-Gremmels, Johanna ; Mantle, Peter ; Peraica, Maja ; Stetina, Rudolf ; Thatcher, Natalie ; Vrabcheva, Terry ; Edler, Lutz

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Final Programme and Abstracts of Lectures and Posters / Van Egmond, HP ; Krska, R ; Bastiaanse HB - Bilthoven : World Mycotoxin Forum, 2012, 140-140

Skup
7th conference of the World Mycotoxin Forum and XIIIth IUPAC International Symposium on Mycotoxins and Phycotoxins

Mjesto i datum
Rotterdam, Nizozemska, 05.11.2012. - 09.11.2012

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
citrinin; risk assessment; food; feed

Sažetak
Citrinin is a mycotoxin produced by several species of the genera Aspergillus, Penicillium and Monascus and occurs mainly in stored grains. The European Food Safety Authority (EFSA) was asked by the European Commission to deliver a scientific opinion on the health risks from citrinin in food and feed. For the exposure assessment, occurrence data submitted to EFSA in response to a call for data and from the literature were examined. Followin an EFSA call for data, analytical results from only 30 samples were submitted by one Member State. The reported citrinin concentrations varied widely in grains both when intended for food (up to 420 µg/kg) and for feed (up to 998 µg/kg), but in general, a high proportion (up to > 90 %) of left censored data were observed. The available occurrence data either submitted to EFSA in response to the call for data or from the literature were not adequate to carry out human and animal dietary exposure assessments. Hazard characterization revealed that citrinin is nephrotoxic and a no-observed-adverse-effect level (NOAEL) of 20 µg/kg body weight (bw) per day was identified from a 90-day study in rats. Due to the limitations and uncertainties in the database, the derivation of a health-based guidance value was not considered appropriate but a level of no concern for nephrotoxicity of 0.2 µg/kg bw per day could be determined. However, based on the available data a concern for genotoxicity and carcinogenicity could not be excluded at the level of no concern for nephrotoxicity. In the absence of adequate exposure data, characterisation of the risk of citrinin as a food contaminant was based on the estimate of the citrinin concentrations in grains and grain-based products that would result in an exposure equal to the level of no concern for nephrotoxicity. For high consuming toddlers, other children and adults this citrinin concentration is between 9 and 53 µg citrinin/kg and between 19 and 100 µg citrinin/kg for average consumers, respectively. For animals, risk characterisation was based on the estimate of the citrinin concentration in grains that would result in exceedance of the NOAEL of 20 µg/kg b.w. per day for pigs, which ranged between 640 and 1 173 µg/kg. The CONTAM Panel concluded that the impact of uncertainties on the risk assessment is large, and more data regarding the toxicity and the occurrence of citrinin in food and feed in Europe are needed to enable refinement of the risk assessment of citrinin.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita

POVEZANOST RADA