Pregled bibliografske jedinice broj: 658199
Genetika multiple skleroze
Genetika multiple skleroze // 2nd International School of Psychiatry and Cognitive Neuroscience - Book of proceedings / Šendula-Jengić, Vesna et al. (ur.).
Rab, Hrvatska, 2011. str. 30-36 (pozvano predavanje, domaća recenzija, cjeloviti rad (in extenso), znanstveni)
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Naslov
Genetika multiple skleroze
(The genetics of multiple sclerosis.)
Autori
Starčević Čizmarević, Nada
Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni
Izvornik
2nd International School of Psychiatry and Cognitive Neuroscience - Book of proceedings
/ Šendula-Jengić, Vesna et al. - , 2011, 30-36
ISBN
978-953-55692-3-7
Skup
2nd International School of Psychiatry and Cognitive Neuroscience
Mjesto i datum
Rab, Hrvatska, 28.10.2010. - 29.10.2010
Vrsta sudjelovanja
Pozvano predavanje
Vrsta recenzije
Domaća recenzija
Ključne riječi
multipla skleroza; genetika
(Multiple sclerosis; genetic)
Sažetak
Multiple sclerosis (MS) is a chronic neuro-inflammatory autoimmune disease believed to arise from complex interactions of both environmental and genetic factors. Typical features for complex genetic diseases include modest heritability without a classic Mendelian mode of transmission and heterogeneity, which mean that variation in a large number of genes contributes to the overall susceptibility. Both human leukocyte antigen (HLA) and a broad spectrum of non-HLA genes have been implicated in the pathogenesis and signalling abnormalities of MS. Identifying susceptibility genes for MS, has been a major challenge in the past two decades. Single-nucleotide polymorphisms (SNPs) within the susceptible genes are appropriate variants able to shed light into the genetic predisposition for MS. Gene/gene interactions, as well as epigenetic mechanisms, are also believed to play an important role for the pathogenesis of complex diseases. Furthermore, distinct forms of MS exist with different underlying genetic causes. Remains an open question which loci are involved in the initial pathogenic events or influence the development and progression of the disease. Even though we are still far from knowing the full set of genes influencing the pathogenesis of MS, considerable success has been made through linkage studies, candidate gene association studies and recently through the successful development of genome-wide association studies (GWAS).
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
