Naslov
Trace elements and inflammatory and oxidative markers in hemodialysis patients

Autori
Jurasović, Jasna ; Mujagić, Renat ; Sekovanić, Ankica ; Vrkić, Nada ; Orct, Tatjana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
X ISTERH Conference Trace Element Research on Health and Diseases ; u: Journal of Trace Elements in Medicine and Biology 27 (2013) (S1) / - , 2013, 40-40

Skup
ISTERH Conference "Trace Element Research on Health and Diseases" (10 ; 2013)

Mjesto i datum
Tokyo, Japan, 18.11.2013. - 22.11.2013

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
biomarkers; essentail elements; chronic hemodyalisis patients; inflammation; oxidatative stress

Sažetak
Oxidative stress, inflammation and trace element imbalance occur in most hemodialysis (HD) patients. In order to test trace element status and the possible influence of inflammatory state and oxidative stress in HD patients on biomarkers in plasma and erythrocytes, we assessed related parameters in 100 HD patients. They included: Fe, Cu, Zn, and Se levels in plasma and erythrocytes, total and non-transferrin Fe, ferritin, C- reactive protein, albumin/globulin, ceruloplasmin, protein carbonylation and superoxide dismutase. Plasma Fe and Cu markers were clearly affected by inflammatory state and oxidative stress, while erythrocyte concentrations remained unaffected. HD patients showed Zn and Se deficiency and apparently normal Fe and Cu plasma levels. In HD patients, Fe and Cu plasma level was not a reliable marker of body status. Using erythrocytes as a marker of trace element status should be evaluated, especially in relation to the role of Fe (indirectly of Cu, as well) for efficient anemia treatment in HD patients.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita, Farmacija

POVEZANOST RADA