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Pregled bibliografske jedinice broj: 654803

Antitumor mechanisms of amino acid hydroxyurea derivatives in the metastatic colon cancer model

Šaban, Nina; Stepanić, Višnja; Vučinić, Srđan; Horvatić, Anita; Cindrić, Mario; Perković, Ivana; Zorc, Branka; Oršolić, Nada; Mintas, Mladen; Pavelić, Krešimir; Kraljević Pavelić, Sandra
Antitumor mechanisms of amino acid hydroxyurea derivatives in the metastatic colon cancer model // International journal of molecular sciences, 14 (2013), 12; 23654-23671 doi:10.3390/ijms141223654 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 654803 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Antitumor mechanisms of amino acid hydroxyurea derivatives in the metastatic colon cancer model

Autori
Šaban, Nina ; Stepanić, Višnja ; Vučinić, Srđan ; Horvatić, Anita ; Cindrić, Mario ; Perković, Ivana ; Zorc, Branka ; Oršolić, Nada ; Mintas, Mladen ; Pavelić, Krešimir ; Kraljević Pavelić, Sandra

Izvornik
International journal of molecular sciences (1422-0067) 14 (2013), 12; 23654-23671

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
colorectal cancer; amino acid hydroxyurea derivatives; HDAC inhibition; anti-proliferative effect

Sažetak
The paper presents a detailed study of the biological effects of two amino acid hydroxyurea derivatives – that showed selective antiproliferative effects in vitro on the growth of human tumor cell line SW620. Tested compounds induced cell cycle perturbations and apoptosis. Proteins were identified by proteomics analyses using two-dimensional gel electrophoresis coupled to mass spectrometry, which provided a complete insight into the most probable mechanism of action on the protein level. Molecular targets for tested compounds were analyzed by cheminformatics tools. Zinc-dependent histone deacetylases were identified as potential targets responsible for the observed antiproliferative effect.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Temeljne medicinske znanosti



POVEZANOST RADA

Projekti:
098-0982464-2511 - Epigenetičke i imunomodulatorne promjene u zloćudnim tumorima glave i vrata (Gall-Trošelj, Koraljka, MZOS ) ( CroRIS)
119-0000000-1255 - Kemoprevencija rasta tumora polifenolnim sastavnicama (Oršolić, Nada, MZOS ) ( CroRIS)
119-0532265-1254 - Imunoadjuvantno i zaštitno djelovanje propolisa u životinja (Benković, Vesna, MZOS ) ( CroRIS)
006-0000000-3216 - Sinteza, karakterizacija i djelovanje potencijalnih i poznatih ljekovitih tvari (Zorc, Branka, MZOS ) ( CroRIS)
335-0000000-3532 - Uloga IGF2 i signalni putovi nizvodno u karcinomima pluća čovjeka (Peter-Katalinić, Jasna, MZOS ) ( CroRIS)
335-0982464-2393 - Molekularna obilježja miofibroblasta Dupuytrenove bolesti (Pavelić, Krešimir, MZOS ) ( CroRIS)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Institut "Ruđer Bošković", Zagreb,
Hrvatska akademija znanosti i umjetnosti,
Prirodoslovno-matematički fakultet, Zagreb,
Fakultet kemijskog inženjerstva i tehnologije, Zagreb,
Sveučilište u Rijeci - Odjel za biotehnologiju

Profili:

Avatar Url Branka Zorc (autor)

Avatar Url Mladen Mintas (autor)

Avatar Url Sandra Kraljević Pavelić (autor)

Avatar Url Ivana Perković (autor)

Avatar Url Višnja Stepanić (autor)

Avatar Url Nina Šaban (autor)

Avatar Url Srđan Vučinić (autor)

Avatar Url Anita Horvatić (autor)

Avatar Url Krešimir Pavelić (autor)

Avatar Url Mario Cindrić (autor)

Avatar Url Nada Oršolić (autor)

Poveznice na cjeloviti tekst rada:

doi fulir.irb.hr www.mdpi.com

Citiraj ovu publikaciju:

Šaban, Nina; Stepanić, Višnja; Vučinić, Srđan; Horvatić, Anita; Cindrić, Mario; Perković, Ivana; Zorc, Branka; Oršolić, Nada; Mintas, Mladen; Pavelić, Krešimir; Kraljević Pavelić, Sandra
Antitumor mechanisms of amino acid hydroxyurea derivatives in the metastatic colon cancer model // International journal of molecular sciences, 14 (2013), 12; 23654-23671 doi:10.3390/ijms141223654 (međunarodna recenzija, članak, znanstveni)
Šaban, N., Stepanić, V., Vučinić, S., Horvatić, A., Cindrić, M., Perković, I., Zorc, B., Oršolić, N., Mintas, M., Pavelić, K. & Kraljević Pavelić, S. (2013) Antitumor mechanisms of amino acid hydroxyurea derivatives in the metastatic colon cancer model. International journal of molecular sciences, 14 (12), 23654-23671 doi:10.3390/ijms141223654.
@article{article, author = {\v{S}aban, Nina and Stepani\'{c}, Vi\v{s}nja and Vu\v{c}ini\'{c}, Sr\djan and Horvati\'{c}, Anita and Cindri\'{c}, Mario and Perkovi\'{c}, Ivana and Zorc, Branka and Or\v{s}oli\'{c}, Nada and Mintas, Mladen and Paveli\'{c}, Kre\v{s}imir and Kraljevi\'{c} Paveli\'{c}, Sandra}, year = {2013}, pages = {23654-23671}, DOI = {10.3390/ijms141223654}, keywords = {colorectal cancer, amino acid hydroxyurea derivatives, HDAC inhibition, anti-proliferative effect}, journal = {International journal of molecular sciences}, doi = {10.3390/ijms141223654}, volume = {14}, number = {12}, issn = {1422-0067}, title = {Antitumor mechanisms of amino acid hydroxyurea derivatives in the metastatic colon cancer model}, keyword = {colorectal cancer, amino acid hydroxyurea derivatives, HDAC inhibition, anti-proliferative effect} }
@article{article, author = {\v{S}aban, Nina and Stepani\'{c}, Vi\v{s}nja and Vu\v{c}ini\'{c}, Sr\djan and Horvati\'{c}, Anita and Cindri\'{c}, Mario and Perkovi\'{c}, Ivana and Zorc, Branka and Or\v{s}oli\'{c}, Nada and Mintas, Mladen and Paveli\'{c}, Kre\v{s}imir and Kraljevi\'{c} Paveli\'{c}, Sandra}, year = {2013}, pages = {23654-23671}, DOI = {10.3390/ijms141223654}, keywords = {colorectal cancer, amino acid hydroxyurea derivatives, HDAC inhibition, anti-proliferative effect}, journal = {International journal of molecular sciences}, doi = {10.3390/ijms141223654}, volume = {14}, number = {12}, issn = {1422-0067}, title = {Antitumor mechanisms of amino acid hydroxyurea derivatives in the metastatic colon cancer model}, keyword = {colorectal cancer, amino acid hydroxyurea derivatives, HDAC inhibition, anti-proliferative effect} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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