Pregled bibliografske jedinice broj: 65278
Parkinson disease and cytochrome P-450 CYP2D6 genetic polymorphism
Parkinson disease and cytochrome P-450 CYP2D6 genetic polymorphism // Biochemia Medica, vol 10, 6th Alps-Adria congress of clinical chemistry and laboratory medicine-abstracts / Suchanek, Ernest (ur.).
Zagreb: Hrvatsko društvo za medicinsku biokemiju i laboratorijsku medicinu (HDMBLM), 2000. str. 119-20 (poster, domaća recenzija, sažetak, znanstveni)
CROSBI ID: 65278 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Parkinson disease and cytochrome P-450 CYP2D6 genetic polymorphism
Autori
Štefanović, Mario ; Topić, Elizabeta ; Ivanišević, Ana-Maria ; Relja, Maja ; Koršić, Marta
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Biochemia Medica, vol 10, 6th Alps-Adria congress of clinical chemistry and laboratory medicine-abstracts
/ Suchanek, Ernest - Zagreb : Hrvatsko društvo za medicinsku biokemiju i laboratorijsku medicinu (HDMBLM), 2000, 119-20
Skup
6th Alps-Adria congress of clinical chemistry and laboratory medicine
Mjesto i datum
Opatija, Hrvatska, 15.06.2000. - 17.06.2000
Vrsta sudjelovanja
Poster
Vrsta recenzije
Domaća recenzija
Ključne riječi
CYP2D6; Parkinson disease
Sažetak
We investigated the association of inactive CYP2D6 alleles *3, *4, *6, *7 and *8 with Parkinson disease (PD). Genotyping of the 41 patients and 145 healthy volunteers was performed by multiplex-allele specific PCR. Patient's phenotype was predicted from genotypes: extensive metabolizer (EM, two wild-type alleles), poor metabolizer (PM, two deficiency alleles) and intermediate metabolizer (IM, one deficiency and one wild type allele). Allelic frequencies among controls (1.4% 2D6*3 ; 11.0% *4 ; 1.0% *6) and PD group (1.2% 2D6*3 ; 20.7% *4 and 1.2% *6) did not differ significantly (pCHI=0.150). Genotype frequencies for the controls were 2.8% *3/wt, 18.6% *4/wt, 1.4% *4/*4, 1.4% *6/wt and 0.7% *4/*6, while in PD group we found 2.4% *3/wt, 26.8% *4/wt, 7.3% *4/*4, and 2.4% *6/wt. Significant difference was also not observed between groups (pCHI=0.247). PM phenotype distribution between controls and PD was different although not significantly (pCHI=0.093): IM and PM phenotype frequencies were 22.8% and 2.1% - among controls, while among PD patients were 31.7% and 7.3%, respectively. The odds ratio for IM and PM showed no statistical relevance: 1.58 (CI95%: 0.735-3.377) and 3.74 (CI95%: 0.799-17.479), respectively. Despite earlier proposed CYP2D6 mutant alleles genetic susceptibility to PD, results of this study do not confirm the association.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
