Pregled bibliografske jedinice broj: 652540
Optimization of gas chromatographic method for the enantioseparation of arylpropionic non-steroidal anti-inflammatory drug methyl esters
Optimization of gas chromatographic method for the enantioseparation of arylpropionic non-steroidal anti-inflammatory drug methyl esters // Journal of pharmaceutical and biomedical analysis, 39 (2005), 3/4; 531-534 doi:10.1016/j.jpba.2005.04.032 (međunarodna recenzija, članak, znanstveni)
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Naslov
Optimization of gas chromatographic method for the enantioseparation of arylpropionic non-steroidal anti-inflammatory drug methyl esters
Autori
Petrović, Marinko ; Debeljak, Željko ; Blažević, Nikola
Izvornik
Journal of pharmaceutical and biomedical analysis (0731-7085) 39
(2005), 3/4;
531-534
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
separation of enantiomers; nNon-steroidal anti-inflammatory drugs; method optimization; gas chromatography
Sažetak
The gas chromatography (GC) method for enantioseparation of well-known non-steroidal anti-inflammatory drugs ibuprofen, fenoprofen and ketoprofen methyl esters mixture was developed. Best enantioseparation was performed on capillary column with heptakis-(2, 3-di-Omethyl- 6-O-t-butyldimethyl-silyl)--cyclodextrin stationary phase and hydrogen used as a carrier gas. Initial temperature, program rate and carrier pressure were optimized to obtain best resolution between enantiomers.
Izvorni jezik
Engleski
Znanstvena područja
Farmacija
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
