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Pregled bibliografske jedinice broj: 651182

Epigenetic modulation of HeLa cell membrane N-glycome by epigenetic inhibitors and reversibility of inhibition effects in a drug-free environment

Horvat, Tomislav; Barisic, Darko; Dezeljin, Martina; Muzinic, Ana; Herak Bosnar, Maja; Lauc, Gordan; Zoldos, Vlatka
Epigenetic modulation of HeLa cell membrane N-glycome by epigenetic inhibitors and reversibility of inhibition effects in a drug-free environment // Abstracts of the XXII International Symposium on Glycoconjugates, June 23-28, 2013, Dalian, China. / H. Vliegenthar (ur.).
Dalian, Kina: Springer, 2013. str. 419-419 (poster, međunarodna recenzija, sažetak, znanstveni)

CROSBI ID: 651182 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Epigenetic modulation of HeLa cell membrane N-glycome by epigenetic inhibitors and reversibility of inhibition effects in a drug-free environment

Autori
Horvat, Tomislav ; Barisic, Darko ; Dezeljin, Martina ; Muzinic, Ana ; Herak Bosnar, Maja ; Lauc, Gordan ; Zoldos, Vlatka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the XXII International Symposium on Glycoconjugates, June 23-28, 2013, Dalian, China. / H. Vliegenthar - : Springer, 2013, 419-419

Skup
XXII International Symposium on Glycoconjugates

Mjesto i datum
Dalian, Kina, 23.06.2013. - 28.06.2013

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
surface N-glycans; zebularine; 5-aza-2-deoxycytidine; Trichostatin A; HPLC analysis

Sažetak
Deregulation of glycosylation occurs in a wide range of multifactorial diseases and aberrant glyco-phenotypes have been associated with specific pathophysiological states. Glycogenes are one of the groups of cancer-associated genes since changes in glycan structures are hallmarks of many cancers.Cancer-specific changes in glycan biosynthetic pathways are resulting from aberrant expressions of glycosyltransferases and glycosidases, which is often a result of epigenetic changes including DNA methylation and/or histone modifications (acetylation, methylation or phosphorylation). The aberrant gene expression pattern can be potentially restored using various epigenetic inhibitors. To test potential therapeutic usefulness of DNA methylation inhibitors, zebularine and 5- aza-2-deoxycytidine, and histone deacetylation inhibitors, trichostatin A and Na-butyrate, in inducing a reversal of undesired glyco-phenotypes, we developed an HPLC- based method for the analysis of glycan structures from HeLa cells embedded in polyacrylamide gels. In addition, we specifically investigated the preservation of altered glycan profiles over a prolonged period of time in a drug-free environment. Our results emphasize the importance of epigenetic control in the regulation of N-glycosylation, but also suggest the stability of complex biosynthetic pathways responsible for the establishment of glycan profiles in human cells in culture.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA

Projekti:
119-1191196-1224 - Dinamika kromatina i plastičnost genoma (Zoldoš, Vlatka, MZOS ) ( CroRIS)

Ustanove:
Prirodoslovno-matematički fakultet, Zagreb

Profili:

Avatar Url Maja Herak Bosnar (autor)

Avatar Url Vlatka Zoldoš (autor)

Avatar Url Gordan Lauc (autor)

Avatar Url Ana Mužinić (autor)

Avatar Url Tomislav Horvat (autor)

Avatar Url Martina Deželjin (autor)

Citiraj ovu publikaciju:

Horvat, Tomislav; Barisic, Darko; Dezeljin, Martina; Muzinic, Ana; Herak Bosnar, Maja; Lauc, Gordan; Zoldos, Vlatka
Epigenetic modulation of HeLa cell membrane N-glycome by epigenetic inhibitors and reversibility of inhibition effects in a drug-free environment // Abstracts of the XXII International Symposium on Glycoconjugates, June 23-28, 2013, Dalian, China. / H. Vliegenthar (ur.).
Dalian, Kina: Springer, 2013. str. 419-419 (poster, međunarodna recenzija, sažetak, znanstveni)
Horvat, T., Barisic, D., Dezeljin, M., Muzinic, A., Herak Bosnar, M., Lauc, G. & Zoldos, V. (2013) Epigenetic modulation of HeLa cell membrane N-glycome by epigenetic inhibitors and reversibility of inhibition effects in a drug-free environment. U: H. Vliegenthar (ur.)Abstracts of the XXII International Symposium on Glycoconjugates, June 23-28, 2013, Dalian, China..
@article{article, author = {Horvat, Tomislav and Barisic, Darko and Dezeljin, Martina and Muzinic, Ana and Herak Bosnar, Maja and Lauc, Gordan and Zoldos, Vlatka}, year = {2013}, pages = {419-419}, keywords = {surface N-glycans, zebularine, 5-aza-2-deoxycytidine, Trichostatin A, HPLC analysis}, title = {Epigenetic modulation of HeLa cell membrane N-glycome by epigenetic inhibitors and reversibility of inhibition effects in a drug-free environment}, keyword = {surface N-glycans, zebularine, 5-aza-2-deoxycytidine, Trichostatin A, HPLC analysis}, publisher = {Springer}, publisherplace = {Dalian, Kina} }
@article{article, author = {Horvat, Tomislav and Barisic, Darko and Dezeljin, Martina and Muzinic, Ana and Herak Bosnar, Maja and Lauc, Gordan and Zoldos, Vlatka}, year = {2013}, pages = {419-419}, keywords = {surface N-glycans, zebularine, 5-aza-2-deoxycytidine, Trichostatin A, HPLC analysis}, title = {Epigenetic modulation of HeLa cell membrane N-glycome by epigenetic inhibitors and reversibility of inhibition effects in a drug-free environment}, keyword = {surface N-glycans, zebularine, 5-aza-2-deoxycytidine, Trichostatin A, HPLC analysis}, publisher = {Springer}, publisherplace = {Dalian, Kina} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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