Naslov
Genotoxic effect of two bleaching agents on oral mucosa

Autori
Klarić, Eva ; Par, Matej ; Profeta, Ivona ; Kopjar, Nevenka ; Rozgaj, Ružica, Kašuba, Vilena ; Želježić, Davor ; Tarle, Zrinka

Izvornik
Cancer genomics and proteomics (1109-6535) 10 (2013), 5; 209-215

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
genotoxicity test ; hydrogen peroxide ; micronucleus test ; oral mucosa ; tooth bleaching

Sažetak
Aim was to analyze the genotoxic effect of two hydrogen peroxide-containing bleaching products on oral mucosal cells. The research was conducted on 22 individuals divided into two groups. Group 1 used ZOOM2 and group 2 the Opalescence BOOST bleaching agent. Specimens of the gingival and the upper lip mucosa were obtained before, immediately after, and 72 h after the bleaching procedure and were analyzed using a micronucleus test. Seventy-two hours after bleaching treatment with BOOST, samples collected from the oral mucosa exhibited a statistically significant increase of all genotoxicity markers, with large effect sizes (Cohen's d>0.8) observed in the total number of micronuclei (MN), number of cells with 3+ MN, karyolysis and bi-nuclear cells. ZOOM2 treatment showed a significant increase, with medium-to-large effect sizes, in the number of cells with 1 MN, karyolysis, nuclear buds and bi-nuclear cells. Both preparations demonstrated potential genotoxic effects.

Izvorni jezik
Engleski

Znanstvena područja
Dentalna medicina

POVEZANOST RADA