Naslov
Glycans are a novel biomarker of chronological and biological age

Autori
Krištić, Jasminka ; Vučković, Frano ; Menni, Cristina ; Klarić, Lucija ; Keser, Toma ; Bečeheli, Ivona ; Pučić-Baković, Maja ; Novokmet, Mislav ; Mangino, Massimo ; Thaqi, Kujtim ; Rudan, Pavao ; Novokmet, Natalija ; Šarac, Jelena ; Missoni, Saša ; Kolčić, Ivana ; Polašek, Ozren ; Rudan, Igor ; Campbell, Harry ; Hayward, Caroline ; Aulchenko, Yurii ; Valdes, Ana ; Wilson, James F. ; Gornik, Olga ; Primorac, Dragan ; Zoldoš, Vlatka ; Spector, Tim ; Lauc, Gordan

Izvornik
The journals of gerontology. Series A, Biological sciences and medical sciences (1079-5006) 69 (2014), 7; 779-789

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
aging ; glycome ; glycosylation ; immunoglobulin G ; inflammation

Sažetak
Fine structural details of glycans attached to the conserved N- glycosylation site significantly affect function of individual IgG molecules, but also mediate inflammation at the systemic level. By analysing IgG glycosylation in 5117 individuals from four European populations we have revealed very complex patterns of changes of IgG glycosylation with age. Several IgG glycans (including FA2B, FA2G2, FA2BG2) changed considerably with age and the combination of these three glycans can explain up to 58% of variance in chronological age, significantly more than other markers of biological age like telomere lengths. The remaining variance in these glycans strongly correlated with physiological parameters associated with biological age. Thus IgG glycosylation appears to be closely linked with both chronological and biological age. Considering the important role of IgG glycans in inflammation, and since the observed changes with age promote inflammation, changes in IgG glycosylation also seem to represent a factor contributing to aging.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Etnologija i antropologija

POVEZANOST RADA