Naslov
Markers of the obesity and inflammation in patients with metabolic syndrome and on dialysis

Autori
Miler, Marijana ; Šegulja, Dragana ; Nikolac, Nora ; Ćelap, Ivana ; Kačkov, Sanja ; Šimundić, Ana-Maria

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Biochemia Medica / Šimundić, Ana-Maria - Zagreb : Hrvatsko društvo za medicinsku biokemiju i laboratorijsku medicinu (HDMBLM), 2012, A189-A189

Skup
2nd European Joint Congress of EFLM and UEMS and 7th Congress of the Croatian Society for Medical Biochemistry and Laboratory medicine (CSMBLM): Laboratory Medicine at the Clinical Interface

Mjesto i datum
Dubrovnik, Hrvatska, 10.10.2012. - 13.10.2012

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
obesity ; dialysis ; inflammation ; metabolic syndrome

Sažetak
Ackground: Dialysis is an invasive treatment in chronic kidney failure associated with increased activation of inflammatory system. The aim of this study was to examine the difference between concentrations of classic inflammatory marker (C- reactive protein, CRP) and new markers from adipokine family (leptin and resistin) in patients on dialysis and with metabolic syndrome. Materials and methods: Total of 140 patients were included in the study, 55 of them with metabolic syndrome (according to NCETP ATP III criteria), 66 on hemodialysis and 18 on peritoneal dialysis. For all patients body mass index (BMI) was provided. CRP concentration was determined with turbidimetric method on Beckman Coulter AU2700 analyzer (Beckman Coulter, Brea, USA). Concentrations of leptin and resistin were determined with fluorescent bead immunoassay (Bender MedSystems GmbH, Vienna, Austria) on the flow cytometer (Beckman Coulter, Brea, USA). Differences between 3 groups were tested with Kruskal-Wallis test. Results: According to the results, CRP concentration was higher in group of dialyzed patients than in patients with metabolic syndrome (P < 0.001) whereas leptin and resistin concentrations did not differ between groups (P = 0.115 and P = 0.569, respectively). BMI was lower in group of patients on hemodialysis regarding to patients on peritoneal dialysis and with metabolic syndrome (P < 0.001). Conclusions: CRP is increased in dialyzed patients and that probably indicates inflammatory response in dialysis. Since leptin and resistin concentrations are not increased in dialyzed patient, we hypothesize that those markers share some other regulatory mechanisms.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA