Naslov
Genetic association studies in thrombophilia research

Autori
Šimundić, Ana-Maria

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

Izvornik
Special issue of the 10th EFCC Continuous Postgraduate Course in Clinical Chemistry: “New Trends in Classification, Diagnosis and Management of Thrombophilia”, / Šimundić, Ana-Maria ; Muszbek, László ; Topić, Elizabeta ; Horvath, Andrea Rita - Berlin : Walter de Gruyter, 2010, S115-S118

Skup
New Trends in Classification, Diagnosis and Management of Thrombophilia

Mjesto i datum
Dubrovnik, Hrvatska, 23.10.2010. - 24.10.2010

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
trombofilija; genska povezanost; metodologija
(thrombophilia; genetic association; metodology)

Sažetak
Genetic association studies explore the association between genetic polymorphisms and a certain trait, disease or predisposition to disease. It has long been acknowledged that many genetic association studies fail to replicate their initial positive findings. This raises concern about the methodological quality of these reports. Case-control genetic association studies often suffer from various methodological flaws in study design and data analysis, and are often reported poorly. Flawed methodology and poor reporting leads to distorted results and incorrect conclusions. Many journals have adopted guidelines for reporting genetic association studies. In this review, some major methodological determinants of genetic association studies will be discussed.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA