Pregled bibliografske jedinice broj: 649085
The role of anesthetics in the phrenic long term facilitation in rats
The role of anesthetics in the phrenic long term facilitation in rats // abstracts of the 4th Croatian Neuroscience Congress
Zagreb, Hrvatska, 2013. (poster, domaća recenzija, sažetak, znanstveni)
CROSBI ID: 649085 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
The role of anesthetics in the phrenic long term facilitation in rats
Autori
Pecotić, Renata ; Valić, Maja ; Pavlinac Dodig, Ivana ; Carev, Mladen ; Karanović, Nenad ; Valić, Zoran ; Đogaš, Zoran
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Abstracts of the 4th Croatian Neuroscience Congress
/ - , 2013
Skup
Croatian Neuroscience Congress (4 ; 2013)
Mjesto i datum
Zagreb, Hrvatska, 20.09.2013. - 21.09.2013
Vrsta sudjelovanja
Poster
Vrsta recenzije
Domaća recenzija
Ključne riječi
long term facilitation; intermittent hypoxia; reamifentanil; phrenic nerve; opioids
Sažetak
Long term facilitation is a form of respiratory plasticity that is induced following exposures to the repeated episodes of intermittent hypoxia. It represents one of the most studied model of respiratory plasticity and a model of obstructive sleep apnea as well. A variety of different variables could affect manifestation of LTF and the choice of anesthetic might have a great impact. Over the past 30 years in an animal model of paralyzed, bilaterally vagotomized, mechanically ventilated rats, urethane was used as an anesthetic of choice because of its minimal effects on respiratory, cardiovascular, and autonomic nervous system. Adult, male, anesthetized, bilaterally vagotomized, paralyzed and mechanically ventilated Sprague Dawley rats were exposed to an acute intermittent hypoxia (AIH) protocol consisting of 5 hypoxic exposures (9% O2 in air) lasting for 3 min each, separated by hyperoxic (50% O2 in air) 3 minutes periods. Peak phrenic nerve activity, respiratory frequency, and respiratory rhythm parameters were analyzed during hypoxia, as well as at 15, 30, and 60 min after the end of the last hypoxic episode. We investigated effects of volatile anesthetics (sevoflurane and isoflurane), opioid anesthetics (remifentanil) and propofol on the manifestation of phrenic LTF and on hypoxic ventilatory response. Results of our research do highlight the potential caveats that might be associated with the selection of a given anesthetic regime to examine phrenic LTF.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Projekti:
216-2163166-0513 - Neuralna kontrola disanja u budnosti i spavanju (Đogaš, Zoran, MZOS ) ( CroRIS)
216-2163166-3342 - Središnja regulacija kardiovaskularnog i respiracijskog sustava-uloga serotonina (Valić, Maja, MZOS ) ( CroRIS)
Ustanove:
Medicinski fakultet, Split
Profili:
Ivana Pavlinac Dodig
(autor)
Nenad Karanović
(autor)
Zoran Valić
(autor)
Mladen Carev
(autor)
Maja Valić
(autor)
Renata Pecotić
(autor)
Zoran Đogaš
(autor)