Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations

O'Seaghdha, C. M.; ...; Zemunik, Tatijana; Boban, Mladen; Kolčić, Ivana; ...; Rudan, Igor; ...; Polašek, Ozren; ...; Bochud, M.

doi:10.1371/journal.pgen.1003796

Pregled bibliografske jedinice broj: 648182

Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations

(SUNLIGHT consortium ; GEFOS consortium) O'Seaghdha, C. M.; ...; Zemunik, Tatijana; Boban, Mladen; Kolčić, Ivana; ...; Rudan, Igor; ...; Polašek, Ozren; ...; Bochud, M.

Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations // PLOS genetics, 9 (2013), 9; e1003796, 13 doi:10.1371/journal.pgen.1003796 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 648182 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations

Autori
O'Seaghdha, C. M. ; ... ; Zemunik, Tatijana ; Boban, Mladen ; Kolčić, Ivana ; ... ; Rudan, Igor ; ... ; Polašek, Ozren ; ... ; Bochud, M.

Kolaboracija
SUNLIGHT consortium ; GEFOS consortium

Izvornik
PLOS genetics (1553-7390) 9 (2013), 9; E1003796, 13

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
calcium ; genome-wide ; gene

Sažetak
Calcium is vital to the normal functioning of multiple organ systems and its serum concentration is tightly regulated. Apart from CASR, the genes associated with serum calcium are largely unknown. We conducted a genome-wide association meta- analysis of 39, 400 individuals from 17 population-based cohorts and investigated the 14 most strongly associated loci in ≤21, 679 additional individuals. Seven loci (six new regions) in association with serum calcium were identified and replicated. Rs1570669 near CYP24A1 (P = 9.1E-12), rs10491003 upstream of GATA3 (P = 4.8E- 09) and rs7481584 in CARS (P = 1.2E-10) implicate regions involved in Mendelian calcemic disorders: Rs1550532 in DGKD (P = 8.2E-11), also associated with bone density, and rs7336933 near DGKH/KIAA0564 (P = 9.1E-10) are near genes that encode distinct isoforms of diacylglycerol kinase. Rs780094 is in GCKR. We characterized the expression of these genes in gut, kidney, and bone, and demonstrate modulation of gene expression in bone in response to dietary calcium in mice. Our results shed new light on the genetics of calcium homeostasis.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA

Projekti:
MZOS-216-1080315-0293 - Genetska epidemiologija šećerne bolesti tip 1 u populaciji Hrvatske (Zemunik, Tatijana, MZOS ) ( CroRIS)
MZOS-216-1080315-0302 - Odrednice zdravlja i bolesti u općoj i izoliranim ljudskim populacijama (Polašek, Ozren, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Split

Profili:

Mladen Boban (autor)