Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 647193

Remifentanil reversibly abolished phrenic long term facilitation in rats subjected to acute intermittent hypoxia


Ivančev, Božena; Carev, Mladen; Pecotić, Renata; Valić, Maja; Pavlinac Dodig, Ivana; Karanović, Nenad; Đogaš, Zoran
Remifentanil reversibly abolished phrenic long term facilitation in rats subjected to acute intermittent hypoxia // Journal of physiology and pharmacology, 64 (2013), 4; 485-492 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 647193 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Remifentanil reversibly abolished phrenic long term facilitation in rats subjected to acute intermittent hypoxia

Autori
Ivančev, Božena ; Carev, Mladen ; Pecotić, Renata ; Valić, Maja ; Pavlinac Dodig, Ivana ; Karanović, Nenad ; Đogaš, Zoran

Izvornik
Journal of physiology and pharmacology (0867-5910) 64 (2013), 4; 485-492

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
long term facilitation; intermittent hypoxia; remifentanil; phrenic nerve; opioids; long term potentiation; mean arterial blood pressure

Sažetak
The aim was to investigate whether intravenous infusion of remifentanil would depress phrenic long term facilitation (pLTF) evoked by acute intermittent hypoxia (AIH) in adult, male, urethane anaesthetized Sprague-Dawley rats, bilaterally vagotomized, paralyzed and mechanically ventilated. The experimental group received a remifentanil infusion (0.5 μg/kg/min i.v., n=12), whereas the control group (n=6) received saline. Rats were exposed to AIH protocol. Phrenic nerve amplitude (PNA), burst frequency (f) and breathing rhythm parameters (Ti, Te, Ttot) were analyzed during 5 hypoxias and at 15, 30, and 60 minutes after the final hypoxia, and compared to baseline values. At the end of the experiment, the infusion of remifentanil was stopped and phrenic nerve activity was compared to baseline values prior to remifentanil infusion. In the control group, peak phrenic nerve activity (pPNA) significantly increased at 60 min (T60, increase by 138.8±28.3%, p=0.006) after the last hypoxic episode compared to baseline values, i.e. pLTF was induced. In remifentanil treated rats, there were no significant changes in peak phrenic nerve activity at T60 compared to baseline values (decrease by 5.3±16.5%, p>0.05), i.e. pLTF was abolished. Fifteen minutes following cessation of remifentanil infusion, pPNA increased by 93.2plusmn ; 40.2% (p<0.05) and remained increased compared to pre-remifentanil-infusion values for more than 30 minutes, i.e. pLTF could be observed after cessation of the remifentanil infusion. In conclusion, the short acting μ-opioid receptor agonist, remifentanil, reversibly abolished phrenic long term facilitation in urethane anesthetized rats.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
HRZZ-09/165 - Promjene disanja i simpatičke živčane aktivnosti prilikom ponavljanih hipoksija – uloga serotonina (Intermittent_hypoxia) (Valić, Maja, HRZZ ) ( CroRIS)
216-2163166-0513 - Neuralna kontrola disanja u budnosti i spavanju (Đogaš, Zoran, MZOS ) ( CroRIS)
216-2163166-3342 - Središnja regulacija kardiovaskularnog i respiracijskog sustava-uloga serotonina (Valić, Maja, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Split

Citiraj ovu publikaciju:

Ivančev, Božena; Carev, Mladen; Pecotić, Renata; Valić, Maja; Pavlinac Dodig, Ivana; Karanović, Nenad; Đogaš, Zoran
Remifentanil reversibly abolished phrenic long term facilitation in rats subjected to acute intermittent hypoxia // Journal of physiology and pharmacology, 64 (2013), 4; 485-492 (međunarodna recenzija, članak, znanstveni)
Ivančev, B., Carev, M., Pecotić, R., Valić, M., Pavlinac Dodig, I., Karanović, N. & Đogaš, Z. (2013) Remifentanil reversibly abolished phrenic long term facilitation in rats subjected to acute intermittent hypoxia. Journal of physiology and pharmacology, 64 (4), 485-492.
@article{article, author = {Ivan\v{c}ev, Bo\v{z}ena and Carev, Mladen and Pecoti\'{c}, Renata and Vali\'{c}, Maja and Pavlinac Dodig, Ivana and Karanovi\'{c}, Nenad and \DJoga\v{s}, Zoran}, year = {2013}, pages = {485-492}, keywords = {long term facilitation, intermittent hypoxia, remifentanil, phrenic nerve, opioids, long term potentiation, mean arterial blood pressure}, journal = {Journal of physiology and pharmacology}, volume = {64}, number = {4}, issn = {0867-5910}, title = {Remifentanil reversibly abolished phrenic long term facilitation in rats subjected to acute intermittent hypoxia}, keyword = {long term facilitation, intermittent hypoxia, remifentanil, phrenic nerve, opioids, long term potentiation, mean arterial blood pressure} }
@article{article, author = {Ivan\v{c}ev, Bo\v{z}ena and Carev, Mladen and Pecoti\'{c}, Renata and Vali\'{c}, Maja and Pavlinac Dodig, Ivana and Karanovi\'{c}, Nenad and \DJoga\v{s}, Zoran}, year = {2013}, pages = {485-492}, keywords = {long term facilitation, intermittent hypoxia, remifentanil, phrenic nerve, opioids, long term potentiation, mean arterial blood pressure}, journal = {Journal of physiology and pharmacology}, volume = {64}, number = {4}, issn = {0867-5910}, title = {Remifentanil reversibly abolished phrenic long term facilitation in rats subjected to acute intermittent hypoxia}, keyword = {long term facilitation, intermittent hypoxia, remifentanil, phrenic nerve, opioids, long term potentiation, mean arterial blood pressure} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





Contrast
Increase Font
Decrease Font
Dyslexic Font