Pregled bibliografske jedinice broj: 647193
Remifentanil reversibly abolished phrenic long term facilitation in rats subjected to acute intermittent hypoxia
Remifentanil reversibly abolished phrenic long term facilitation in rats subjected to acute intermittent hypoxia // Journal of physiology and pharmacology, 64 (2013), 4; 485-492 (međunarodna recenzija, članak, znanstveni)
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Naslov
Remifentanil reversibly abolished phrenic long term facilitation in rats subjected to acute intermittent hypoxia
Autori
Ivančev, Božena ; Carev, Mladen ; Pecotić, Renata ; Valić, Maja ; Pavlinac Dodig, Ivana ; Karanović, Nenad ; Đogaš, Zoran
Izvornik
Journal of physiology and pharmacology (0867-5910) 64
(2013), 4;
485-492
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
long term facilitation; intermittent hypoxia; remifentanil; phrenic nerve; opioids; long term potentiation; mean arterial blood pressure
Sažetak
The aim was to investigate whether intravenous infusion of remifentanil would depress phrenic long term facilitation (pLTF) evoked by acute intermittent hypoxia (AIH) in adult, male, urethane anaesthetized Sprague-Dawley rats, bilaterally vagotomized, paralyzed and mechanically ventilated. The experimental group received a remifentanil infusion (0.5 μg/kg/min i.v., n=12), whereas the control group (n=6) received saline. Rats were exposed to AIH protocol. Phrenic nerve amplitude (PNA), burst frequency (f) and breathing rhythm parameters (Ti, Te, Ttot) were analyzed during 5 hypoxias and at 15, 30, and 60 minutes after the final hypoxia, and compared to baseline values. At the end of the experiment, the infusion of remifentanil was stopped and phrenic nerve activity was compared to baseline values prior to remifentanil infusion. In the control group, peak phrenic nerve activity (pPNA) significantly increased at 60 min (T60, increase by 138.8±28.3%, p=0.006) after the last hypoxic episode compared to baseline values, i.e. pLTF was induced. In remifentanil treated rats, there were no significant changes in peak phrenic nerve activity at T60 compared to baseline values (decrease by 5.3±16.5%, p>0.05), i.e. pLTF was abolished. Fifteen minutes following cessation of remifentanil infusion, pPNA increased by 93.2plusmn ; 40.2% (p<0.05) and remained increased compared to pre-remifentanil-infusion values for more than 30 minutes, i.e. pLTF could be observed after cessation of the remifentanil infusion. In conclusion, the short acting μ-opioid receptor agonist, remifentanil, reversibly abolished phrenic long term facilitation in urethane anesthetized rats.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Projekti:
HRZZ-09/165 - Promjene disanja i simpatičke živčane aktivnosti prilikom ponavljanih hipoksija – uloga serotonina (Intermittent_hypoxia) (Valić, Maja, HRZZ ) ( CroRIS)
216-2163166-0513 - Neuralna kontrola disanja u budnosti i spavanju (Đogaš, Zoran, MZOS ) ( CroRIS)
216-2163166-3342 - Središnja regulacija kardiovaskularnog i respiracijskog sustava-uloga serotonina (Valić, Maja, MZOS ) ( CroRIS)
Ustanove:
Medicinski fakultet, Split
Profili:
Ivana Pavlinac Dodig
(autor)
Nenad Karanović
(autor)
Mladen Carev
(autor)
Maja Valić
(autor)
Renata Pecotić
(autor)
Zoran Đogaš
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE