Pregled bibliografske jedinice broj: 645494
Distinct role of Taf14 protein in regulation of SAGA-dependent, TATA-containing genes in yeast
Distinct role of Taf14 protein in regulation of SAGA-dependent, TATA-containing genes in yeast // Book of abstracts of the 3RD congress of croatian geneticists with international participation / Franekić, Jasna ; Garaj-Vrhovac, Verica (ur.).
Krk, Hrvatska, 2012. (predavanje, nije recenziran, sažetak, ostalo)
CROSBI ID: 645494 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Distinct role of Taf14 protein in regulation of SAGA-dependent, TATA-containing genes in yeast
Autori
Nemet, Josipa ; Jeličić, Branka ; Sopta Marija-Mary
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo
Izvornik
Book of abstracts of the 3RD congress of croatian geneticists with international participation
/ Franekić, Jasna ; Garaj-Vrhovac, Verica - , 2012
ISBN
978-953-57128-0-0
Skup
Croatian genetic society 3RD congress of croatian geneticists with international participation
Mjesto i datum
Krk, Hrvatska, 13.05.2012. - 16.05.2012
Vrsta sudjelovanja
Predavanje
Vrsta recenzije
Nije recenziran
Ključne riječi
Taf14 protein; transcription regulation
Sažetak
Taf14, a Saccharomyces cerevisiae protein, physically associates with many critical multisubunit complexes including the general transcription factors TFIID and TFIIF, the chromatin modifying complexes SWI/SNF, INO80, RSC and NuA3. Taf14 is a member of the YEATS superfamily of proteins, conserved from bacteria to higher eukaryote, with substantial potential for role in chromatin remodeling mechanisms. Considering poorly described role of Taf14 protein we investigated impact of TAF14 deletion on genome wide transcription in yeast. A range of recent genome wide studies give fascinating insight into cellular strategies for keeping gene expression in tune with physiological needs dictated by the environment. Stress-related genes generally contain TATA boxes, have a predominant regulation by SAGA versus TFIID, prefer negative versus positive regulation by chromatin, and possess higher plasticity of expression. Our transcriptome analysis uncovers that TATA-containing and SAGA- dependent genes were much more affected by TAF14 deletion than were TFIID-dependent genes. We show that Taf14 repressed genes tend to be extensively regulated, , positively by SAGA complex and stress activators and negatively by wide number of repressors that act upon promoter chromatin and TBP.
Izvorni jezik
Engleski
Znanstvena područja
Biologija
