Naslov
Targeting Toll-Like Receptors: a step closer to effective recombinant subunit vaccines

Autori
Bendelja, Krešo ; Rabatić, Sabina

Izvornik
Periodicum biologorum (0031-5362) 114 (2012), 2; 211-220

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
TLR; urođena imunost; stečena imunost; cjepiva
(pathogen-associated molecular motif; Toll-like receptors; innate immunity; adaptive immunity; vaccine)

Sažetak
The control and prevention of infectious diseases through immunization is one of the greatest achievements of modern medicine since Edward Jenner pioneered smallpox vaccination. However, future challenges in improving the efficacy of existing vaccines, development of new prophylactic vaccines for infectious diseases and therapeutic immunization for noninfectious diseases require extensive work to reveal key components of the molecular immune mechanism involved. Successful activation of innate immune response is a prerequisite for successful immunization and activation of adaptive immunity. Innate immune system comprises numerous evolutionary conserved pattern-recognition receptors (PRRs) that bind structural components shared by many pathogens. Upon binding the ligand, cascade reaction results in de novo gene expression required for immediate immune response by innate immunity and the activation of specific immune response mediated by the humoral and cellular mediators. Appropriate selection of specific pattern-recognition receptor ligands (adjuvants) enables formulation of the next generation vaccines, with controlled minimal adverse symptoms and efficient adaptive immunity development.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA