Pregled bibliografske jedinice broj: 643440
Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1γ
Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1γ // Proceedings of the National Academy of Sciences of the United States of America, 110 (2013), 41; 16550-16555 doi:10.1073/pnas.1310215110 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 643440 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1γ
Autori
Trsan, Tihana ; Busche, A. ; Abram, Maja ; Wensveen, Felix ; Lemmermann, N.A. ; Arapović, Maja ; Babić, Marina ; Tomić, Adriana ; Golemac, Mijo ; Brinkmann, M.M. ; Jäger, W. ; Oxenius, A. ; Polić, Bojan ; Krmpotić, Astrid ; Messerle, M. ; Jonjić, Stipan
Izvornik
Proceedings of the National Academy of Sciences of the United States of America (0027-8424) 110
(2013), 41;
16550-16555
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
CD8 T cell vaccine; RAE-1 gamma; vaccine vector
Sažetak
Due to a unique pattern of CD8 T-cell response induced by cytomegaloviruses (CMVs), live attenuated CMVs are attractive candidates for vaccine vectors for a number of clinically relevant infections and tumors. NKG2D is one of the most important activating NK cell receptors that plays a role in costimulation of CD8 T cells. Here we demonstrate that the expression of CD8 T-cell epitope of Listeria monocytogenes by a recombinant mouse CMV (MCMV) expressing the NKG2D ligand retinoic acid early-inducible protein 1-gamma (RAE-1γ) dramatically enhanced the effectiveness and longevity of epitope-specific CD8 T-cell response and conferred protection against a subsequent challenge infection with Listeria monocytogenes. Unexpectedly, the attenuated growth in vivo of the CMV vector expressing RAE-1γ and its capacity to enhance specific CD8 T-cell response were preserved even in mice lacking NKG2D, implying additional immune function for RAE-1γ beyond engagement of NKG2D. Thus, vectors expressing RAE-1γ represent a promising approach in the development of CD8 T-cell-based vaccines.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Projekti:
062-0621261-1263 - Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru (Jonjić, Stipan, MZOS ) ( CroRIS)
062-0621261-1268 - Uloga imunosubverzivnih citomegalovirusnih gena u latenciji (Krmpotić, Astrid, MZOS ) ( CroRIS)
062-0621261-1271 - Uloga NKG2D u razvoju, homeostazi i efektorskim funkcijama imunološkog sustava (Polić, Bojan, MZOS ) ( CroRIS)
Ustanove:
Medicinski fakultet, Rijeka
Profili:
Astrid Krmpotić
(autor)
Bojan Polić
(autor)
Tihana Tršan
(autor)
Felix Martinus Wensveen
(autor)
Mijo Golemac
(autor)
Maja Arapović
(autor)
Stipan Jonjić
(autor)
Maja Abram
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
- EconLit