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Pregled bibliografske jedinice broj: 643088

Pain sensitivity and analgesis response in Wistar- Zagreb 5HT rats with constitutionally altered serotonin transporter


Kesić, Maja; Tvrdeić, Ante; Čičin-Šain, Lipa
Pain sensitivity and analgesis response in Wistar- Zagreb 5HT rats with constitutionally altered serotonin transporter // Abstracts of the 7th Croatian Congress of Pharmacology ; u: Periodicum Biologorum 115 (2013) (S3) / Vitale, Branko (ur.).
Zagreb: Hrvatsko prirodoslovno društvo ; Institut Ruđer Bošković ; Laser Plus, 2013. str. 71-71 (poster, domaća recenzija, sažetak, znanstveni)


CROSBI ID: 643088 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Pain sensitivity and analgesis response in Wistar- Zagreb 5HT rats with constitutionally altered serotonin transporter

Autori
Kesić, Maja ; Tvrdeić, Ante ; Čičin-Šain, Lipa

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the 7th Croatian Congress of Pharmacology ; u: Periodicum Biologorum 115 (2013) (S3) / Vitale, Branko - Zagreb : Hrvatsko prirodoslovno društvo ; Institut Ruđer Bošković ; Laser Plus, 2013, 71-71

Skup
Croatian Congress of Pharmacology (7 ; 2013)

Mjesto i datum
Zagreb, Hrvatska, 18.09.2013. - 21.09.2013

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
pain; serotonin; Wistar-Zagreb 5HT rats

Sažetak
It is known that serotonin (5-hydroxytryptamine, 5HT) system modulates nociceptive response acting through both, central and peripheral nervous system, but its contribution to pain sensitivity and analgesic response remained to be fully understood. Here, we studied serotonergic modulation of pain behaviour using a genetic animal model of rats with constitutional differences in 5HT homeostasis (Wistar-Zagreb 5HT rats), developed by selective breeding for the extreme activities of peripheral 5HT transporter (5HTT). Besides in periphery, two sublines (high- 5HT and low-5HT) of this model differ also in the central 5HT homeostasis, as evidenced from neurochemical and behavioural studies. By measuring paw withdrawal latency (PWL) to the radiant heat stimulation (Hargreaves test) we assessed 1) baseline thermal pain sensitivity and 2) analgesic effect of various drugs (tramadol, clomipramine, fluvoxamine) in animals from high- 5HT and low-5HT sublines. We demonstrated that, in acute model of nociception, animals from the high- 5HT subline are less sensitive to thermal stimuli at baseline (have higher PWL values) and that animals from the low-5HT subline show better response to selected analgesic drugs (tramadol, clomipramine), when compared to the counterpart low-5HT subline. Observed differences in pain sensitivity and analgesic response between high- 5HT and low-5HT sublines support a contribution of 5HT system and, specifically, functional 5HTT in the control of pain behaviour. Results also validate our Wistar- Zagreb 5HT rats as a potential model to study the role of endogenous 5HT tone in the physiology and pharmacology of pain perception/behaviour.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
098-1081870-2397 - Serotonergični mehanizmi u alkoholizmu (Čičin-Šain, Lipa, MZOS ) ( CroRIS)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Ante Tvrdeić (autor)

Avatar Url Lipa Čičin-Šain (autor)

Avatar Url Maja Kesić (autor)


Citiraj ovu publikaciju:

Kesić, Maja; Tvrdeić, Ante; Čičin-Šain, Lipa
Pain sensitivity and analgesis response in Wistar- Zagreb 5HT rats with constitutionally altered serotonin transporter // Abstracts of the 7th Croatian Congress of Pharmacology ; u: Periodicum Biologorum 115 (2013) (S3) / Vitale, Branko (ur.).
Zagreb: Hrvatsko prirodoslovno društvo ; Institut Ruđer Bošković ; Laser Plus, 2013. str. 71-71 (poster, domaća recenzija, sažetak, znanstveni)
Kesić, M., Tvrdeić, A. & Čičin-Šain, L. (2013) Pain sensitivity and analgesis response in Wistar- Zagreb 5HT rats with constitutionally altered serotonin transporter. U: Vitale, B. (ur.)Abstracts of the 7th Croatian Congress of Pharmacology ; u: Periodicum Biologorum 115 (2013) (S3).
@article{article, author = {Kesi\'{c}, Maja and Tvrdei\'{c}, Ante and \v{C}i\v{c}in-\v{S}ain, Lipa}, editor = {Vitale, B.}, year = {2013}, pages = {71-71}, keywords = {pain, serotonin, Wistar-Zagreb 5HT rats}, title = {Pain sensitivity and analgesis response in Wistar- Zagreb 5HT rats with constitutionally altered serotonin transporter}, keyword = {pain, serotonin, Wistar-Zagreb 5HT rats}, publisher = {Hrvatsko prirodoslovno dru\v{s}tvo ; Institut Ru\djer Bo\v{s}kovi\'{c} ; Laser Plus}, publisherplace = {Zagreb, Hrvatska} }
@article{article, author = {Kesi\'{c}, Maja and Tvrdei\'{c}, Ante and \v{C}i\v{c}in-\v{S}ain, Lipa}, editor = {Vitale, B.}, year = {2013}, pages = {71-71}, keywords = {pain, serotonin, Wistar-Zagreb 5HT rats}, title = {Pain sensitivity and analgesis response in Wistar- Zagreb 5HT rats with constitutionally altered serotonin transporter}, keyword = {pain, serotonin, Wistar-Zagreb 5HT rats}, publisher = {Hrvatsko prirodoslovno dru\v{s}tvo ; Institut Ru\djer Bo\v{s}kovi\'{c} ; Laser Plus}, publisherplace = {Zagreb, Hrvatska} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus





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