Pregled bibliografske jedinice broj: 642115
Pathogenesis, modulation, and therapy of Alzheimer’s disease: A perspective on roles of liver-X receptors
Pathogenesis, modulation, and therapy of Alzheimer’s disease: A perspective on roles of liver-X receptors // Translational Neuroscience, 4 (2013), 3; 349-356 doi:10.2478/s13380-013-0136-z (međunarodna recenzija, pregledni rad, znanstveni)
CROSBI ID: 642115 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Pathogenesis, modulation, and therapy of Alzheimer’s disease: A perspective on roles of liver-X receptors
Autori
Štefulj, Jasminka ; Panzenboeck, Ute ; Hof, Patrick R. ; Šimić, Goran
Izvornik
Translational Neuroscience (2081-3856) 4
(2013), 3;
349-356
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni
Ključne riječi
Alzheimer’s disease ; neurodegeneration ; Amyloid-beta ; cholesterol ; liver-X receptors ; LXR agonists ; neuroinflammation ; Transgenic mouse models
Sažetak
The pathogenesis of Alzheimer’s disease (AD) has been mostly linked to aberrant amyloid beta (Aβ) and tau proteins metabolism, disturbed lipid/cholesterol homeostasis, and progressive neuroinflammation. Liver X receptors (LXR) are ligand-activated transcription factors, best known as the key regulators of cholesterol metabolism and transport. In addition, LXR signaling has been shown to have significant anti-inflammatory properties. In this brief review, we focus on the outcome of studies implicating LXR in the pathogenesis, modulation, and therapy of AD.
Izvorni jezik
Engleski
Znanstvena područja
Biologija, Temeljne medicinske znanosti
POVEZANOST RADA
Projekti:
HRZZ-IS-09/16 - Otkrivanje i praćenje bioloških biljega radi rane terapijske intervencije u Alzheimerovoj bolesti (Šimić, Goran, HRZZ ) ( CroRIS)
MZOS-098-1081870-2395 - Serotonergična neurotransmisija: geni, proteini i ponašanje (Štefulj, Jasminka, MZOS ) ( CroRIS)
MZOS-108-1081870-1942 - Fosforilacija tau proteina u razvitku i Alzheimerovoj bolesti (Šimić, Goran, MZOS ) ( CroRIS)
Ustanove:
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb,
Hrvatsko katoličko sveučilište, Zagreb
Poveznice na cjeloviti tekst rada:
Pristup cjelovitom tekstu rada doi www.degruyter.com fulir.irb.hrCitiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
Uključenost u ostale bibliografske baze podataka::
- BIOSIS Previews (Biological Abstracts)
