Naslov
Paraoxonase polymorphism in cardiovascular diseases (CAD)

Autori
Ivanišević, Ana-Maria ; Štefanović, Mario ; Topić, Elizabeta ; Nikolić, Vjeran ; Petrač, Dubravko ; Čubrilo-Turek, Mirjana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
European Journal of Human Genetics : Programme and abstracts / Van Ommen, Gert-Jan B. - Hampshire : Stockton Press, 1999, 131-132

Skup
31st Annual Meeting of the European Society for Human Genetics

Mjesto i datum
Ženeva, Švicarska, 29.05.1999. - 01.06.1999

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
PON1 gene; cardiovascular diseases

Sažetak
Paraoxonase (PON1) genetic polymorphism at codon 192 (glutamine to arginine substitution, genotypes A and B, respectively) has been shown to affect the risk of CVD. The aim of this study was to genotype 44 controls and 100 CVD patients with different diagnosis (coronary artery disease (CAD), myocardial infarction (MI), hypertension and carotid stenosis (CS)) by PCR-RFLP using Alw1 restriction enzyme. Study results showed that out of 44 controls 18/44 (40.9%) were A and 1/44 (2.3%) B homozygotes and 25/44 (56.8%) heterozygotes. Among 31 CAD patients 9/31 (29.0%) were A and 5/31 (16.1%) B homozygotes and 17/31 (54.8%) heterozygotes. In 27 MI patients 8/27 (29.6%) were A and 4/27 (14.8%) B homozygotes and 15/27 (55.6%) heterozygotes. Out of 16 hypertension patients 6/16 (37.5%) were A and 3/16 (18.8%) B homozygotes and 7/16 (43.8%) heterozygotes. Among 26 CS patients 15/26 (57.7%) were A and 2/26 (7.7%) B homozygotes and 9/26 (34.6%) heterozygotes. Genotypes between controls and patients differed significantly (Chi-square test ; P=0.002, 0.003, <0.001 and 0.003 ; for CAD, MI, Hypertension and CS patients, respectively). Allelic frequencies did not differ significantly between controls and patients. Our findings indicate the association between the codon 192 polymorphism of PON1 gene and cardiovascular diseases.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

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