Naslov
Association of hsp70-2 (+1267A/G) and hsp70-hom (+2437T/C) polymorphisms with cerebral atherosclerosis in Croatian population

Autori
Barišić, Karmela ; Matokanović, Mirela ; Galović, Ružica ; Ravlić, Magdalena

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the 38th FEBS Congress “Mechanisms in Biology” ; u: The FEBS Journal 280 (2013) (S1) ; SW01-W4-13 / - Cambridge : Wiley-Blackwell, 2013, 77-77

Skup
FEBS Congress: “Mechanisms in Biology” (38 ; 2013)

Mjesto i datum
Sankt Peterburg, Ruska Federacija, 06.07.2013. - 11.07.2013

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
hsp70-hom; hsp70-2; stenosis of cerebral arteries (SCA); Croatian population; SNP

Sažetak
The aim of this study was to test for a possible association of hsp70- 2 (+1267A/G) and hsp70-hom (+2437T/C) polymorphisms with ste- nosis of cerebral arteries (SCA) in the Croatian population. The genotyping of DNA, isolated from the whole blood of 51 patients with SCA and 48 healthy controls, was performed. Frag- ment size analysis upon restriction enzyme digestion was used for genotype/allele definition. The significance of findings was tested using the v2 test. hsp70-2 (+1267A/G) polymorphism was associated signifi- cantly with SCA. The results of genotyping analysis indicated that the genotype AG was associated preferentially with SCA (p = 0.039). No association for hsp70-hom (+2437T/C) polymor- phism was found. The study results support the existence of an association of hsp70- 2 (+1267A/G) polymorphism with cerebral atherosclerosis. A higher frequency of the AG genotype in Croatian patients was observed. There was no evidence for an association of hsp70-hom (+2437T/C) polymorphism with cerebral atherosclerosis.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

Napomena
DOI: 10.1111/febs.12340

POVEZANOST RADA