Naslov
Pharmaceutically acceptable salts of memantine and their crystal forms

Autori
Tuksar, Mihaela ; Žegarac, Miroslav ; Brdar, Biljana ; Lekšić, Edislav ; Meštrović, Ernest

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
23rd Croatian Meeting of Chemist and Chemical eng Engineers, Book of Abstract / - Zagreb : Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2013

Skup
23rd Croatian Meeting of Chemist and Chemical eng Engineers

Mjesto i datum
Osijek, Hrvatska, 21.04.2013. - 24.04.2013

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
Memantine; Solid state; Crystal structure; Drug

Sažetak
Memantine Hydrochloride, chemically 1-amino-3, 5-dimethyladamantane is an active pharmaceutical substance, available in the product marketed under the brands Namenda®, Axura® and Ebixa®. It is used in treatment of moderate to severe Alzheimer’s type dementia. It is estimated that there were 36 million people living with dementia worldwide in 2010., increasing to 66 million by 2030. and 115 million by 2050. Although there is no cure to reverse effects of Alzheimer’s disease, Memantine (Figure 1.) can help manage symptoms of the disease. It acts as an uncompetitive antagonist at glutameric NMDA receptors improving the exchange of signals between cells in the brain essential to learning and memory functions. Memantine Hydrogensulfate and Memantine Dihydrogenphosphate are successfully prepared and characterized. On the basis of current research, due significantly better crystal morphology and hygroscopicity, Memantine Hydrogensulfate is a good candidate to be an alternative salt to Memantine Hydrochloride for future formulation studies

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Farmacija

POVEZANOST RADA