Naslov
Prognostic value of lymphovascular space invasion in endometrial cancer

Autori
Puljiz, Mario ; Puljiz, Željko ; Danolić, Damir ; Alvir, Ilija ; Tomica, Darko ; Mamić, Ivica ; Vučemilo, Tiha ; Perić Balja, Melita ; Zorica, Robert

Izvornik
Medicinski glasnik Ljekarske komore Zeničko-dobojskog kantona (1840-0132) 10 (2013), 2; 288-292

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
uterus ; tumor cells ; metastasis ; recurrence

Sažetak
Aim To evaluate the prognostic significance of lymphovascular space invasion (LVSI) in endometrial cancer (EC) patients. Methods A total of 73 patients who underwent surgery for endometrial cancer at the University Hospital for Tumors, Zagreb, Croatia and University Hospital Centre Split, Croatia, in the period from 1999 to 2008 were evaluated. Results Lymphovascular space invasion was identified in 58 cases (79.5%). Univariate analysis and multivariate analysis demonstrated a significant association between LVSI and EC recurrence (p=0.004 ; HR 0.241, CI 0.114–0.511). The median time from diagnosis to EC recurrence of patients with positive LVSI was 20months, and the median time from diagnosis to EC recurrence of patients with negative LVSI was 86 months (relative risk of recurrence 0.24). Conclusion Lymphovascular space invasion identified on routine haematoxylin and eosin stained sections, is a significant independent predictor of endometrial cancer recurrence.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA