Pregled bibliografske jedinice broj: 637228
NKG2D -dependent and -independent immune function of RAE-1: superior induction and maintenance of protective CD8 T cells in mice infected with MCMV vector expressing RAE-1'
NKG2D -dependent and -independent immune function of RAE-1: superior induction and maintenance of protective CD8 T cells in mice infected with MCMV vector expressing RAE-1' // Seminar on Immunology - Medical Immunology Campus Erlangen
Erlangen, Njemačka, 2013. (pozvano predavanje, međunarodna recenzija, pp prezentacija, znanstveni)
CROSBI ID: 637228 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
NKG2D -dependent and -independent immune function of RAE-1: superior induction and maintenance of protective CD8 T cells in mice infected with MCMV vector expressing RAE-1'
Autori
Jonjić, Stipan
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, pp prezentacija, znanstveni
Skup
Seminar on Immunology - Medical Immunology Campus Erlangen
Mjesto i datum
Erlangen, Njemačka, 01.07.2013. - 02.07.2013
Vrsta sudjelovanja
Pozvano predavanje
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
MCMV; NKG2D ligand Rae-1; innate immunity
Sažetak
The story is about the interesting finding that MCMV vector expressing NKG2D ligand RAE-1 and foreign CD8 epitope induces robust CD8 response, in spite of its dramatic attenuation in vivo. We worked out the mechanism to some extent and it looks like such a virus enhances direct antigen presentation. Above all, by using NKG2D k.o. mouse, we also observed this enhancing immunogenicity of this virus vector, suggesting that there must be another immune function for RAE-1.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Projekti:
062-0621261-1263 - Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru (Jonjić, Stipan, MZOS ) ( CroRIS)
Ustanove:
Medicinski fakultet, Rijeka
Profili:
Stipan Jonjić
(autor)
