Pregled bibliografske jedinice broj: 636469
Berberine exerts nephroprotective effect against cisplatin-induced kidney damage through inhibition of oxidative/nitrosative stress, inflammation, autophagy and apoptosis
Berberine exerts nephroprotective effect against cisplatin-induced kidney damage through inhibition of oxidative/nitrosative stress, inflammation, autophagy and apoptosis // Food and chemical toxicology, 62 (2013), 397-406 doi:10.1016/j.fct.2013.09.003 (međunarodna recenzija, članak, znanstveni)
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Naslov
Berberine exerts nephroprotective effect against cisplatin-induced kidney damage through inhibition of oxidative/nitrosative stress, inflammation, autophagy and apoptosis
Autori
Domitrović, Robert ; Cvijanović, Olga ; Pernjak- Pugel, Ester ; Škoda, Marko ; Mikelić, Lorena ; Crnčević-Orlić, Željka
Izvornik
Food and chemical toxicology (0278-6915) 62
(2013);
397-406
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
berberine; cisplatin nephrotoxicity; oxidative stress; inflammatory response; autophagy; apoptosis
Sažetak
The aim of this study was to investigate the therapeutic activity of isoquinoline alkaloid berberine against cisplatin (CP)-induced nephrotoxicity in mice. Berberine was administered at daily doses of 1, 2 and 3 mg/kg by gavage for two succesive days, 48 h after intraperitoneal CP injection (13 mg/kg). Mice were sacrificed 24 h after the last dose of berberine. Histopathological changes and the increase in serum creatinine and blood urea nitrogen (BUN) induced by CP were significantly ameliorated by berberine in a dose-dependent manner. Additionally, oxidative/nitrosative stress, evidenced by the increase in renal 4- hydroxynonenal (4-HNE), 3-nitrotyrosine (3-NT), cytochrome P450 E1 (CYP2E1) and heme oxygenase (HO-1) expression, was significantly reduced. The expression of nuclear factor-kappaB (NF- κB), tumor necrosis factor-α (TNF-α), cyclooxygenase-2 (COX- 2) and inducible nitric oxide synthase (iNOS) was markedly suppressed by berberine, indicating the inhibition of inflammatory response. Treatment of CP- intoxicated animals with berberine also significantly reduced the expression of p53, active caspase-3 as well as autophagy marker light chain 3B (LC3B) in the kidneys. The results of the current study showed the nephroprotective activity of berberine against CP-induced renal injury, which could be attributed to the inhibition of oxidative/nitrosative stress, inflammation, autophagy and apoptosis.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti, Farmacija
POVEZANOST RADA
Projekti:
062-0000000-3554 - Aktivni sastojci ljekovitog bilja u terapiji fibroze jetre (Domitrović, Robert, MZOS ) ( CroRIS)
062-0620226-0208 - Kost kao ciljni organ u šećernoj bolesti i upalnim bolestima crijeva (Crnčević Orlić, Željka, MZOS ) ( CroRIS)
062-0621261-1269 - Perinatalni citomegalovirusni encefalitis (Pernjak-Pugel, Ester, MZOS ) ( CroRIS)
Sveučilište u Rijeci
potpora 13.06.1.2.24
Ustanove:
Medicinski fakultet, Rijeka,
Klinički bolnički centar Rijeka
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE