Pregled bibliografske jedinice broj: 636141
Structural Elucidation Studies of 15-Membered Azalide Macrocycles using H/D Exchange and ESI-MSn
Structural Elucidation Studies of 15-Membered Azalide Macrocycles using H/D Exchange and ESI-MSn // Journal of pharmaceutical and biomedical analysis, 86 (2013), 1-10 doi:10.1016/j.jpba.2013.07.011 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 636141 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Structural Elucidation Studies of 15-Membered Azalide Macrocycles using H/D Exchange and ESI-MSn
Autori
Gembarovski, Dubravka ; Gabelica Marković, Vesna ; Galić, Nives
Izvornik
Journal of pharmaceutical and biomedical analysis (0731-7085) 86
(2013);
1-10
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
15-Membered Azalide Aglycone; macrolides; ESI-MSn; H/D exchange; fragmentation; sodium adducts
Sažetak
A comprehensive study of fragmentation pathways of 15-membered azalide macrocycles using electrospray ionisation with multistage mass spectrometry (ESI-MSn) is presented in this work. Hydrogen/deuterium (H/D) exchange experiments and high-resolution mass spectrometry were used to investigate the proposed fragmentation pathways. In addition, the fragmentation patterns of sodium adduct ions [M+Na]+ of the macrocycles were also investigated as the presence of an alkali metal interacting with the aglycone ring influences the product-ion spectra.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
POVEZANOST RADA
Projekti:
119-1191342-1083 - Interakcije i dizajn bioaktivnih molekula (Novak, Predrag, MZOS ) ( CroRIS)
119-1191342-2960 - Elektroliti i koordinacijske reakcije u otopini (Tomišić, Vladislav, MZOS ) ( CroRIS)
Ustanove:
Prirodoslovno-matematički fakultet, Zagreb,
Fidelta d.o.o.
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
