Naslov
Hyperbaric oxygen is effective in early stage of healing of experimental brain abscess in rats

Autori
Bilić, Ivica ; Petri, Nadan ; Krstulja, Mira ; Vučković, Meri ; Salamunić, Ilza ; Kraljević Šiško, Katarina ; Čapkun, Vesna ; Lušić, Ivo

Izvornik
Neurological research (0161-6412) 34 (2012), 10; 931-936

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
brain abscess; experimental model; healing; hyperbaric oxygen; neoangiogenesis; Staphyloccocus aureus

Sažetak
Current therapy of brain abscess (BA) includes a combined approach that involves antibiotics and minimal invasive surgery, but also hyperbaric oxygen treatment (HBOT) as a supportive measure. Optimum treatment is still a matter of significant controversy. The experiment, previously approved by a relevant ethical commitee, involved 80 female Wistar rats. BA was experimentally induced by inoculation of Staphyloccocus aureus. The animals were randomized into groups and treated either with antibiotics, HBOT, or with a combination of both. Beneficial effect of HBOT was evident in groups treated with HBOT or with a combination of antibiotic + HBOT. It was mainly manifested on days three and five of the experiment and was evident as statistically significant increase of a number of newly formed blood vessels, increase in mean vascular density, and smaler abscess necrotic core. Althought the results of the present study should be interpreted cautiously, they suggest that HBOT has an important but limited role in the treatment of BA.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA